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Andre Delacourte on Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

COMMENT This paper is not really in favor of the cascade hypothesis: The neuroprotective role of sAPP could be lost in AD, in parallel to the amyloid marker. Loss of function of APP is not a part of the amyloid cascade (gain of toxic function). Second, in the ...

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