40 RESULTS
COMMENT This paper represents impressive work. Hou et al performed a series of intriguing experiments, focusing on the potential substrate map of one of the most promiscuous enzymes–γ-secretase–and on its role in microglial activation. First, they conducted mass
COMMENT Using in-house-developed STARmap PLUS for single-cell spatial transcriptomics, Zeng et al. established a cellular map that reflects disease pathology in the TauPS2APP transgenic model of Alzheimer’s disease. The beautiful data shown here nicely corroborat
COMMENT In this exciting study, Lengerich and Zhan et al. have grafted the transferrin receptor (TfR) binding site onto two anti-TREM2-stalk-region antibodies to boost the antibody delivery into the CNS in an amyloid mouse model. In line with the previous work wi
COMMENT Ever since its discovery in 2010, the function of Piezo1 has been widely characterized in different tissues and cell types, in both physiological and pathological contexts. However, little was known regarding its role in microglia. Here, Jin Hu et al. sho
COMMENT Jain et al. report surprising results that chronically activating TREM2 after plaque formation increases neuritic plaque (NP)-tau pathology and Aβ-associated tau spreading when 5XFAD mice brains are injected with human tau aggregates. The results showed,
COMMENT In their recent preprint in bioRXiv, Dolan and colleagues report an in vitro platform utilizing human stem-cell-derived microglia (iMGLs) that allows for viral manipulation and high-throughput screens. They show that exposing iMGLs to central nervous syst
COMMENT Mancuso et al. presented an exciting piece of work, taking advantage of the xenotransplantation model for AD, where human microglia precursors were transplanted into immunodeficient amyloid pathology mouse models. Through single-cell RNA-Seq, they identif
COMMENT This is an inspiring study. Our group (Wang et al., 2020), among others (Schlepckow et al., 2020; Cheng et al., 2018; Fassler et al., 2021; Price et al., 2020), had previously proposed and studied the possibility of TREM2-based immunotherapy in the AD mou
COMMENT The paper by Blurton-Jones and colleagues nicely demonstrates that the genetic depletion of microglia alters amyloid pathology in a unique way, different from the outcomes of pharmacological depletion of microglia. The authors utilized FIRE mice (Rojo et
COMMENT comment. mcolonna_246206 0 TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function
COMMENT Wyss-Coray and colleagues previously reported that microglia in aged mice express CD22, which functions as an inhibitory receptor of phagocytosis (Pluvinage et al., 2019). Although their follow-up study (Pluvinage et al., 2021) did not find expression of
COMMENT In this new study, Xie et al. report a novel role for TREM2 in microglial responses in an AAV-expressed, human TDP-43 model of amyotrophic lateral sclerosis (ALS), and they provide evidence of physical interactions between TREM2 and TDP-43. The authors pr
COMMENT Szykowska et al. have described four novel scFvs selected by phage display that bind to human TREM2, and the crystal structures of two with highest binding affinity/avidity. According to the reported structures of scFv-2- and scFv-4-TREM2 complexes, both
COMMENT I wish to congratulate the authors for their exciting publication and valuable contribution. Meningeal B cells have been hiding in plain sight, and yet they have received little attention. I believe that our studies will pave the way for a fertile line of
COMMENT This interesting study by Hu et al. presented two take-home messages. First, subpopulations of AD-reactive microglia are senescent. By studying the APP/PS1 mouse model, the authors showed that activated microglia proliferate around amyloid plaques, which
