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Paul Coleman on Genetics of Alzheimer's disease: recent advances.

COMMENT There may be more than one factor contributing to the probabilistic nature of the relationship between genes and risk of late-onset AD. The author recognizes one: the complexity of the disease. An entirely different, and not mutually exclusive, factor ...

Paul Coleman on Spine Shrinkers: Aβ Oligomers Caught in the Act

COMMENT The paper by Koffie et al., by showing correlation between oligomeric Aβ and PSD loss, adds significantly to our appreciation of mechanisms by which flavors of APP, especially of Aβ, attack synapses in Alzheimer disease. There are now publications that ...

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