Gregory Cole on Acetaminophen Derivative Tempers Microglia, Spurs Plaque Clearance
COMMENT This very nice and extensively documented report demonstrates the efficacy of a new small molecule (DAPPD) that inhibits NF-κB pathway-mediated activation of microglia by Aβ to restore microglial amyloid clearance in two lines of APP/PS1 mutant mice. They ...