John Cirrito on Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms.
COMMENT Ting et al. provide an interesting and well-done analysis of how endogenous Abeta may depress synaptic transmission, namely by depressing AMPA receptor-mediated EPSCs. Also, the authors find subtle presynaptic deficits in synaptic vesicle cycling with ...