Roberta Diaz Brinton on Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease.
COMMENT A limitation of mouse models of Alzheimer disease has been the lack of neuronal loss. This report indicates a substantial and remarkable loss of interneurons in a knock-in presenilin-1 mutation mouse model. Typically, interneurons have been resistant to c