SEARCH RESULTS

52 RESULTS

Steve Barger on Caspase activation precedes and leads to tangles.

COMMENT There is a good chance that caspases play a physiological role in synaptic plasticity. Mattson and colleagues (1998a; 1998b) showed that activated caspases could be detected in synaptosome preparations and distal dendrites of intact cells. Although their

Steve Barger on APP Makes a Calcium Connection in Neurons

COMMENT The finding that APP depletion can result in aberrations in calcium-channel function and synaptic function is interesting for reasons beyond the "protein’s normal role in neurons." We reported a little over a year ago that APP is severely deplet

Steve Barger on The Brain Minus Microglia—No Effect on Plaques

COMMENT The demonstration by Grathwohl et al. that substantial depletion of microglia has no consequences for Aβ deposition is indeed intriguing. However, this finding must be taken in context of a good deal of data indicating that microglia do participate in the

Steve Barger on Microglia—Medics or Meddlers in Dementia

COMMENT El Khoury et al. have produced a dataset that adds to those indicating a beneficial role for monocytic phagocytes (either activated microglia or hematogenous macrophages) with respect to the development of Alzheimer-related pathology. Some data have indic

Current Filters

  • TYPE: Comment x
  • Commentator: Barger, Steve x

Remove all filters

Filter By

DATE RANGE
  • All
  • Past 7 Days
  • Past 30 Days
  • Past 90 Days
  • Past 12 Months
  • Specific Dates
    1. From
      To

TYPE