483 RESULTS
COMMENT Aducanumab was first developed by Roger Nitsch and Christoph Hock of Neurimmune when they started searching for naturally occurring autoantibodies to Aβ oligomers from memory B-cells of super agers. Roger is generous in his presentations to point out that
COMMENT The paper by Lauwers et al. is a timely reminder of the transmissible properties of amyloid fibrils. This is a story that started in the 1960s with the observations of the systemic amyloid researchers using experimental models of what is now known as AA a
COMMENT Linse et al. present a kinetic study of the influence of four amyloid-directed antibodies, developed to treat Alzheimer’s disease, on aspects of the complex process of amyloid-β aggregation. This is an advancement on our own efforts and those of others to
COMMENT required. —Hideyuki Takahashi is a co-author of this comment. stephen.strittmatter 0
COMMENT amyloidopathy and tauopathy, and the subsequent commentary. In their Alzforum comments posted on 5 Feb 2019,
COMMENT Boon et al. describe a novel type of amyloid plaque that is specifically seen in early onset Alzheimer’s disease (AD) cases who have apolipoprotein (APOE) ε4/4 status (Boon et al., 2020). The association of these plaques with capillary cerebral amyloid an
COMMENT There are ample clearing mechanisms in the body for proteins such as amyloid. We know that there is a turnover of amyloid, so to speculate that there may be some detrimental effect from tiny amounts of amyloid in the body is stretching the likelihood of p
COMMENT This is a very nice example of functional follow-up of a genetic association study finding. I am very happy that this is taking place (it’s why we are performing the studies) and of course I am pleased it looks like the genetic association studies were ri
COMMENT Takalo et al. present an interesting paper on an AD-associated protective variant in PLCG2 by making a Plcγ2-P522R knock-in (KI) mouse model. The authors showed that the Plcγ2-P522R mutation increased PLCγ signaling and promoted phagocytosis, survival, an
COMMENT A P522R coding variant in the PLCγ2 gene was recently demonstrated to reduce the risk of Alzheimer’s disease (AD). This study by Takalo et al. is the first to examine how the P522R variant impacts microglial activity in vivo and it provides additional dat
COMMENT Lauwers and colleagues present a helpful synopsis of the potential risk of human transmission of β-amyloid pathology by contaminated neurosurgical equipment and blood transfusions. The authors point out that the current evidence to support iatrogenic tran
COMMENT How strange that researchers focus on the patients, who get one brain operation each. Largely ignored is a possible risk to neurosurgeons, who all day are exposed to brain after brain, accompanied by glove nicks, sharps penetrations, and cautery smoke plu
COMMENT With Peter's death, we have all lost a major leader in the AD field. It is really very sad. sambak 0
COMMENT As underlined in this paper, to date, the risk of transmission associated with Aβ pathology during neurosurgery remains uncertain. Data are limited and inconclusive. In my opinion, they are by far insufficient to delay or forgo any necessary neurosurgery
COMMENT I’m not an expert on this precise topic. That said, we have considered this issue here in France and Professor Duyckaerts, myself, and others participated in a scientific committee that was convened on this topic in 2016. I was asked specifically to focus
