483 RESULTS
COMMENT I hope that this experiment can be repeated in a human CD33 transgenic mouse that has been crossed into an Alzheimer's model. There is strong unpublished evidence to suggest that CD33 is involved in the regulation of the phagocytosis or trogocytosis
COMMENT This elegant study by Richetin and colleagues has several interesting and important findings. In human participants with Alzheimer's disease, 3R tau accumulation was observed in astrocytes in the hippocampus, specifically the hilus of the dentate gyr
COMMENT This is a very interesting study that highlights the susceptibility of astrocytes to preferentially acquire pathological features in the form of confirmation-specific isoforms of tau in hippocampal regions burdened by Alzheimer pathology. Seeking to under
COMMENT In this important study, Richetin et al. demonstrate that astrocytes in the hilus of the hippocampus dentate gyrus accumulate misfolded 3R-tau in Alzheimer’s disease (AD). Using an elegant lentiviral gene transfer approach in vivo (wild-type mice) and in
COMMENT Like Séverine Boillée’s landmark observations in 2003, this elegant study once more highlights the therapeutic potential of myeloid cells in motor neuron disease. It would be fascinating to find out how and which bone marrow- and yolk-sac-derived macropha
COMMENT The negative vote on Biogen’s aducanumab filing by the FDA Advisory Committee constitutes a clear setback for future availability of this antibody to oligomeric Aβ for Alzheimer patients. The basis for this vote, and its implications, needs to be carefull
COMMENT We will see the results of further studies based on the amyloid hypothesis as studies continue to be pursued globally. We and others have suggested important caveats to interpreting clinical trial results. Broader thinking is now occurring across the Alzh
COMMENT It’s not over yet! We all wanted to believe that aducanumab would spell the beginning of the end of AD-related dementia. But the evidence that this promising anti-amyloid treatment might buck the unfortunate historical trend haunting anti-amyloid treatmen
COMMENT Time to think outside the box Common sense has prevailed. The failing approach to AD therapy we have implemented so far reflects the faulty attitude we have toward neurodegeneration (Hurtley and Alderton, 202 0). A growing body of evidence supports the no
COMMENT This was the most unusual Advisory Committee meeting we've ever listened to. The opinions that were expressed were extremely positive or negative across the board, with very few participants having both positive and negative feedback. The complete di
COMMENT With respect to the similarity of "each copy of APOE4" data and "all-inclusive PGS" data, and the analogy between the immune response of ages 4-20 and 70-95, I wonder whether the middle age group really does not have an intrinsic facto
COMMENT In this study, Chiot and colleagues investigate the role of peripheral macrophages, located along peripheral motor neuron axons, and microglia, which surround the spinal motor neuron soma, in ALS. The authors use busulfan and transplantation of GFP+ bone
COMMENT These findings raise many questions. Are the peripheral macrophages affected prior to the CNS microglia being harmed? Is it a direct effect on the macrophages or are the macrophages indirectly affected by other cells, such as altered T regulatory cells or
COMMENT The study by Kim and colleagues sheds light on how α-synuclein released from neurons affects a LRRK2-mediated signaling cascade in microglia to promote neuroinflammation. It has been known for some time that LRRK2 is present in the brain in both neurons a
COMMENT This work has several objectives: (i) to establish a systematic mapping of transposase-accessible chromatin (ATAC) regions in seven brain regions from 39 healthy individuals; (ii) from some of the samples used in the previous bulk assay, to perform a simi
