106 RESULTS
COMMENT This paper carries forward an emerging theme in the literature, which they reference, that Alzheimer’s disease is a network disease of the brain. By that I mean that the anatomy, or the space the disease occupies, conforms to what has been dubbed the brai
COMMENT The value of a method seeking to detect a specific pathogen depends on its sensitivity and on the usage of checks such as exclusion of false negatives and positives, e.g., by recovery experiments. In the case of PCR, the sensitivity can depend on the targ
COMMENT This is a fascinating and very significant study by Yambire et al. that, I think, has important implications for understanding the molecular mechanism by which mutations in the PRESENILIN genes, and possibly APP, contribute to early onset familial Alzheim
COMMENT This work by Franzmeier and colleagues is an elegant study that further illuminates the relationship between tau deposition and the functional network architecture of the brain. A particularly interesting outcome of the work lies in the discovery of a lon
COMMENT Different regions of the brain are differentially affected by plaque and tangle pathology, with the cerebral cortex and hippocampus being the primary targets. Subcortical regions are also affected. The noradrenergic locus coeruleus (LC) is involved in the
COMMENT The paper shows a series of logically linked experiments using human brain tissue, wild-type mice, two lines of mice producing excessive Aβ, and neuronal cultures. It demonstrates that Aβ oligomers can bind allosterically to α 2A AR receptors of the norep
COMMENT This is an excellent study providing new insights and a rich resource on TREM2-dependent glial responses in AD in mice and humans. One highlight of the study is the description of reactive oligodendrocytes in the 5xFAD mouse model of AD. Using snRNAseq, t
COMMENT This is a very informative and important paper. We should remember that there are no "mouse models of AD." Maybe we will never see any animal model that fully mimics Alzheimer’s disease (see Walker and Jucker, 2017). What we have are mouse model
COMMENT The study by Allnutt et al. reports the application of a computational approach for the detection of microbial sequences to two existing RNA-sequence data sets (MSBB and ROSMAP) to examine potential microbial associations with Alzheimer’s disease. The aut
COMMENT This work by Allnut et al. complements our analysis on whether HHV6 and 7 are elevated in AD brains compared to control. Our analysis is focused on the validity of the method used to test whether there is a statistical significance to the HHV virus level
COMMENT As compared to the Readhead paper, which with sophisticated bioinformatics tools proved a functional association with AD and its viral risk factors, here Jacobson and colleagues use a single bioinformatic pipeline, utilizing the same data set and same bra
COMMENT We have known for some time that Aβ and tau interact with each other and that Aβ can trigger and exacerbate tau pathology, but the molecular mechanisms have not been fully defined. The present study shows that Aβ oligomers (Aβ o) can act as a positive all
COMMENT I wish to congratulate Zhou et al. for this exceptional article. One of the genes that attracted my attention was SERPINA3 (aka alpha-1-antichymotrypsin). We published that alpha-1-antichymotrypsin (ACT) was intimately associated with amyloid plaques in A
COMMENT This a wonderful discussion of an important topic in the vascular contributions to dementia. It is important to contextualize that these results pertain specifically to atherosclerosis and not other forms of vascular dysfunction. Gottesman et al. is consi
COMMENT Among the now several “-omics” papers on Alzheimer’s disease that have emerged in the last few years, this new report by Zhou et al. stands out because of its comprehensive analysis of mouse and human tissue at the single-cell level. One of the more obvio
