387 RESULTS
COMMENT This is a significant finding. The authors have established here that neuroligin-3 (NL3) plays a critical role in controlling the properties of excitatory synapses on parvalbumin (PV) interneurons in the CA1 region of the hippocampus. The upshot is the mo
COMMENT This is a very interesting paper centered on TRIM28, which was found by phenotypic screens to stabilize tau and α-synuclein and promote their nuclear localization. TRIM28 is a member of the TRIM family, of which there are ~100 in the human genome. We have
COMMENT This study examined the biochemical interaction between poly(PR) and the nuclear pore. They found that poly(PR) binds to polymeric forms of the FG repeat domain found in several nuclear pore proteins, providing molecular mechanistic insight into the toxic
COMMENT "Amplification bias" is certainly an issue that needs to be considered when fibril structures from brain tissue are amplified by seeded growth. Certain structures may self-propagate more efficiently than others, depending on the precise details
COMMENT This is a very nice study. The authors demonstrate that greater adherence to a Mediterranean-type diet is related to slower rates of brain atrophy change over three years (over and above a series of potential confounders). There were previous reports of s
COMMENT High-resolution structures of γ-secretase have revealed the architecture of one of the most intriguing proteases. Moreover, co-structures with the allosteric inhibitor DAPT and a short co-purifying peptide uncovered the pocket and interaction mode for DAP
COMMENT are also co-authors of this comment. Lars.Lannfelt dag.sehlin hanna.laudon_239096
COMMENT The paper reports the findings of a study conducted in Ontario, Canada, using linkage techniques across multiple databases. The study was possible because of the unique availability of routinely collected medical and environmental data for millions of res
COMMENT The choice of dose requires both a dose-ranging safety assessment (done with both single and multiple doses in Phase 1) and some reasonably definitive measure of efficacy (usually accomplished by dose-ranging studies in Phase 2, and not usually done in Ph
COMMENT Steven Paul raises some interesting points, but surely the earlier Phase 1 work would have been the primary basis, toxicology aside, for the choice of dose? r.g.m.morris_196916 0
COMMENT I think it’s great to have new methods to assess rare variability in cohorts of families. Different methods have different limitations so it’s good to see novel, apparently robust approaches to use family based whole-exome and whole-genome sequencing data
COMMENT This study by Brocker et al. reveals an interesting finding of beneficial effects on PD motor symptoms when using an optimized stimulation sequence with lower average frequency (45 Hz) than the traditional DBS settings (130 to 185 Hz). It is, however, imp
