Ather Malik on Cholinesterase Inhibitors Not What They're Cracked Up To Be?
COMMENT This study could not guarantee correct typing of dementias. As such, non-AD cases could have been included. Ather.Malik 0
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Gladys Brown on Schizophrenia Drugs Said to Raise Stroke Risk in Dementia Patients
COMMENT patients would notice and comment on her needs before staff took requisite actions. The presence of her
Jeffrey Cummings on Cholinesterase Inhibitors Not What They're Cracked Up To Be?
COMMENT of cost effectiveness, i.e., a payer perspective. Several aspects of the study deserve comment
John Morris on Cholinesterase Inhibitors Not What They're Cracked Up To Be?
COMMENT The AD2000 study reported in The Lancet is an important article, and Lon Schneider's editorial also is important. The findings were that "donepezil produces small improvements in cognition and activities of daily living in patients with mild to
Mary Reid on For Better Memory, Try Keeping Your HAT On…
COMMENT Which of the human sirtuins might target FKHR? Might we suspect SIRT2, as North et al. (1) find that it is a tubulin deacetylase. Hempen et al. (2) report decreased acetylated alpha-tubulin in neurofibrillary tangle-bearing neurons in AD. Does the overexp
Bart Dermaut on Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.
COMMENT We are very intrigued by the two recent papers (Feng et al., 2004; Saura et al., 2004) showing neurodegeneration and tau hyperphosphorylation in PS null mouse brains. Although at first sight the non-amyloid neuropathology doesn’t appear to be directly rel
Paul Coleman on Cell Death: Time to Push It Out of the Doldrums
COMMENT Don't Lock the Barn Door After the Horse is Gone Yong Shen presents a comprehensive review of molecular phenomena related to neuron death in AD. Yet I suggest that his major contention deals with an event that is not one that leads to the major clini
Mary Reid on For Better Memory, Try Keeping Your HAT On…
COMMENT I see that many of the signs of Rubenstein-Taybi syndrome are also reported in Down's syndrome. The study by Branchi et al. (1) finding that overexpression of DYRK1A results in increased phosphorylation of FKHR, high levels of cyclin B1 and increased
Kiminobu Sugaya on Neurogenic effect of beta-amyloid peptide in the development of neural stem cells.
COMMENT While Aβ toxicity has received much research focus, its physiological function was overlooked in the past. We have reported that neural stem cells (NSC) transplanted into amyloid precursor protein (APP)-transgenic mouse brain preferentially differentiated
Stephen Robinson on The Pathogen Hypothesis
COMMENT When will the pathogen hypothesis catch on? The idea that Alzheimer's disease is caused by a pathogen which invades the brain has been around for decades, but this notion has never attracted serious attention from mainstream researchers. It is often
jan keegan ronk on Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study.
COMMENT The answer is in the paper. If women on Prempro show an increase in dementia, it therefore shows a connection. These women, however, may have worsened without the use of the drug. Too simplistic. The variables are too all over the study to be of any use.
Li-Huei Tsai on Cell Death: Time to Push It Out of the Doldrums
COMMENT Yong pointed out in his reply posted 6/24/2004 that the role of cyclin-dependent kinase 5 (Cdk5) in the pathology and death of neurons is important. Identified over a decade ago as tau-phosphorylating entities purified from brain lysates, Cdk5 and GSK3 ha
Sam Gandy on Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study.
COMMENT Hormone Replacement: Is There a Pony in Here Anywhere? In remembering President Reagan's optimistic outlook, several of his friends recounted the story that, when presented with a barn full of horse manure, Reagan would probably respond with the line
Sam Gandy on Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study.
COMMENT Hormone Replacement: Is There a Pony in Here Anywhere? In remembering President Reagan's optimistic outlook, several of his friends recounted the story that, when presented with a barn full of horse manure, Reagan would probably respond with the line
Paul Mathews on Influence of the amyloid precursor protein locus on dementia in Down syndrome.
COMMENT I agree with Rachael Neve that this is an interesting report suggesting that APP is causally involved in Down's syndrome dementia. Of relevance to this story is a recent report by Anne Cataldo et al. demonstrating that APP gene dosage modulates an AD