11170 RESULTS
COMMENT It's too early to say this is a final failure just because of a one-time experiment, However, if we ascribe insomina of AD patients only to their shortness of melatonin, it should be unbelieveable. Until now, we do not know the exact cause(s) and mea
COMMENT This was a useful article for me because my sleep is often disrupted because of my need to urinate. There have also been times when I have thought that I was becoming incontinent. With this information I will be much more assiduous about strengthening my
COMMENT As cholinergic M1 receptor blockage will inhibit the production of NGF and possibly decrease sAPPalfa formation one should be aware that prolonged anticholinergic treatment could enhance the neurdegeneration of cholinergic neurons in the Meynert nucleus a
COMMENT The Case Report by Drs. Tsao and Heilman calls needed attention to a syndrome, often mimicking that of a dementing illness, of potentially reversible cognitive dysfunction associated with anticholinergic drugs used for the treatment of common bladder dist
COMMENT For stem cell researchers, this is an encouraging report which indicates neurogenesis in the Alzheimer's disease (AD) patient's brain. If this finding is true, just increasing the stem cell population in the patient’s brain might help to regener
COMMENT A mechanism to inhibit partially PS1 expression without modifying Notch activity has been postulated in our recent paper in FEBS Letters. It should be noted that the compound used is physiologically produced in the right amount in young people and strongl
COMMENT This paper demonstrates rapid Ca2+-dependent de-ubiquitination of synaptic proteins. Using a classical biochemical preparation of synaptosomes, which are pinched-off nerve terminals with attached postsynaptic elements capable of neurotransmitter release,
COMMENT Tools to selectively knock down specific mRNA species in cells and tissues have developed at a spectacular pace over the past few years (reviewed by Scherer and Rossi, 2003). A major advance was the development of short interfering RNA technology (siRNA),
COMMENT On the basis of a brief abstract this appears interesting because it helps elucidate pathways of an agent that, along with valproic acid, is being considered for AD therapeutics. 0 Paul_Coleman
COMMENT The paper by Satpute-Krishnan et al. links the seemingly disparate worlds of amyloid and herpesviruses via the more neutral domain of the giant axon of the squid—the fons et origo of our knowledge about nerve conduction/impulses. The aim was to investigat
COMMENT The selective presence of large numbers of Ig+-neurons and their association with an apoptotic phenotype in AD brain tissue versus healthy controls is very interesting, and certainly suggests a possible B cell-mediated autoimmune component to disease. An
COMMENT This paper is most significant because it establishes that cholesterol plays a regulatory role in vivo in the pathogenesis of the AD lesions. 0 sjuliete1
COMMENT The recent paper by Rego and Oliveira has fully described the role of mitochondrial abnormalities as a key target, not only as ATP producers through oxidative phosphorylation, but also as regulators of intracellular Ca2+ homeostasis and endogenous produce
COMMENT Perhaps the authors could comment on this. In complex genetic studies like this where the significance of
COMMENT I am really happy that science is going to immunotherapy of Alzheimer's disease. I presented some of my data at the 6th International Conference on Alzheimer's Disease and Related Disorders, July 1998 in Amsterdam, The Netherlands, and this data
