Yong Shen on Cell Death: Time to Push It Out of the Doldrums
COMMENT transmission is one event that affects learning and memory. Paul indicated in the comments that "synapses
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Andre Delacourte on Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.
COMMENT This paper is not really in favor of the cascade hypothesis: The neuroprotective role of sAPP could be lost in AD, in parallel to the amyloid marker. Loss of function of APP is not a part of the amyloid cascade (gain of toxic function). Second, in the cas
Mary Reid on Fish Oil Swims Ahead in Dietary Brain Protection Race
COMMENT Does this study support a dissociation between LTP and spatial memory? Itokazu and colleagues (1) report that DHA inhibits the induction of long-term potentiation in the CA1 area in rats, as is shown to be the case for Aβ in many studies. I'd also be
Takaomi Saido on Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.
COMMENT To my knowledge, this is the first paper demonstrating the relationship between presenilin and inflammation, which might be associated with the paticular agressive nature of FAD caused by PS1 mutations. It seems, however, necessary and important to make a
Inez Vincent on Protein kinase CK2 is an inhibitor of the neuronal Cdk5 kinase.
COMMENT This is a beautifully done study and is timely. It will and should shift the focus in the field of Cdk5 biology to regulation of Cdk5 activity beyond p35 and p25. It also emphasizes the importance of cross-talk between Cdk5 and other protein kinases in ne
David Teplow on Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity.
COMMENT Waking up demented: New ideas about anesthesia-induced cognitive impairment In an intriguing paper just published in Anesthesiology, Eckenhoff et al. seek an explanation for the commonly observed transitory, and sometimes persistent, cognitive impairment
Mark Cookson on Lysosomes and Proteasomes Compete for PD Researchers' Attention
COMMENT Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy Expression levels of α-synuclein are correlated with Parkinson’s disease in several ways. The most extreme example is the finding of a triplication of the normal wild-type gene in
Colin Meyer on Fish Oil Swims Ahead in Dietary Brain Protection Race
COMMENT With regard to the recent focus upon a diet rich in fish and its protective effect against Alzheimer's disease, please allow me to point out that the assumption that this is attributable to omega-3 fatty acids may be misguided. There are two groups o
GREG GUTGSELL on Gingko Goes on Trial Again…This Time in London
COMMENT since September 2003. Her current stage is now diagnosed as early middle AD. Any comments? gguts12 0
Steven Greenberg on Study Poses Cautionary Question: Will Knocking Down Aβ42 Promote Amyloid Angiopathy?
COMMENT The beautiful series of papers by Jucker and colleagues begin to paint a picture of how cerebrovascular amyloid deposition (or CAA) might occur: 1. Neuronally produced Aβ peptide appears to have the opportunity to deposit in the brain parenchyma as plaque
John Trojanowski on Lysosomes and Proteasomes Compete for PD Researchers' Attention
COMMENT Mechanisms leading to the formation of α-synuclein inclusions in Parkinson's disease (PD) and related α-synucleinopathies characterized predominantly by abundant fibrillary intracellular α-synuclein inclusions in neurons and their processes as well a
Roger Kamm on Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains.
COMMENT This paper presents, for the first time, a quantitative method for predicting the rate of aggregation into filaments or other larger structures based on intrinsic (amino acid sequence, charge, hydrophobicity) and extrinsic (pH, ionic content, concentratio
Tomasz Sobow on Gingko Goes on Trial Again…This Time in London
COMMENT Interesting trial and...a nice try at the same time. Using too low a dose will generate no clear answers on gingko efficacy. In my opinion, the arm of 120 mg of gingko versus 240 mg of gingko versus placebo would be rational advice. So far, both doses hav
Andre Delacourte on The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor.
COMMENT From this paper, one should ask—if AICD is dysregulated in AD—if yes, if this dysregulation is playing a role in the neurodegenerating process (loss of function of APP due to aberrrant nuclear signalling), and if amyloid is not a marker of this dysmetabol
Farhan Ul Haq Subhani on Staring into the Eyes of Death—Measuring Apoptosis One Neuron at a Time
COMMENT This is a good effort, and I think that it would be important in the field of retinal disease. It is clear that the retinal and hippocampal neurons are much different. Being sensitive to light, the retinal neurons have different physiological levels. Reti