11174 RESULTS
COMMENT I agree wholeheartedly with Dr. Kjellin. I was very surprised when I reviewed the AD2000 protocol closely and realized that the study design allowed frequent and long washout periods and in the statistical design did not analyze the donepezil 5 mg and 10
COMMENT There was a 15,000-person study in Finland of carrot consumption and heart disease. No improvement was noticed. This study was about five years ago (seen in a newspaper). Have you seen any thing about using liquorice to increase memory? A concentrate was
COMMENT I believe it is the time to finally admit that Elan’s AN-1792 trial is a failure! There is no clear evidence on cognitive benefits, neither on global measures nor on neuropsychological tests; moreover, in a subset of subjects a potentially fatal complicat
COMMENT Unfortunately I couldn't make this conference but the reports are fascinating. We have argued for some time that certain plaque types are particularly dense (e.g. fibrillar and dense-core plaques) and act as microscopic 'space-forming' lesi
COMMENT appreciate more comments by the experts on the AD2000 protocol in regard to all those quite long washout
COMMENT Wow! lgnmatrix 0
COMMENT Additional insight on the role of statins in Alzheimer's is provided in the recent article by Rebeck and another by Koudinov and Koudinova, as well as in several articles listed at the Noteworthy collections of the Neurobiology of Lipids. postmaster
COMMENT Tobias is right, of course. It is only through formal experiment that one can test such specifics as dose and duration of treatment. The fact remains that the epi data gave the statins story a huge "shot in the arm," and the new data from the pr
COMMENT Epidemiological data are just one of the many things in the toolbox. Perfect as hypothesis factory, but then to be tested by entirely different methods. But do these and other statin-epi studies tell us whether to continue or discontinue therapeutic appro
COMMENT A point of clarification about my presentation: Prescribing bias could indeed account for some of the results in the Jick study, but Jick's design DID assure that statin exposures were antecedent to onset of clinical dementia. Thus, the timing issue
COMMENT I read Yong Shen's review on molecular events of neuron death in AD, and the comments, with
COMMENT Aβ has superoxide dismutase activity. Might Aβ synthesis be upregulated due to a compensatory reaction to reduced Cu,Zn-SOD activity? Kang (1) reports that methylglyoxal modifies Cu,Zn-SOD with a resultant loss of enzyme activity and copper leaving the pr
COMMENT In their recent article, Liu et al provided clear evidence that abnormal hyperphospharylation of tau protein may be induced by decreased 0-GlcNAcylation subsequent to a deficient glucose metabolism in Alzheimer disease (AD) brain. Experimentally, the auth
COMMENT I find this paper a significant contribution to the field, and one that will undoubtedly engender further work and exploration into potential new therapeutics. This is important for the Alzheimer's field because new approaches designed to increase ve
COMMENT comment by Dr. Ming Chen posted July 12 is somewhat misleading. Dr. Chen states that the “age-related
