David Holtzman on ABCA1 Links Cholesterol and ApoE, But It May Not Be a Risk Factor for AD
COMMENT ABCA1 has been shown to be critical outside the brain for effluxing phospholipid and cholesterol from cells onto HDL. In the periphery, ApoAI is the main apolipoprotein in HDL. The absence of ABCA1 function results in Tangier's disease in which plasm