11174 RESULTS
COMMENT I agree with Rachael Neve that this is an interesting report suggesting that APP is causally involved in Down's syndrome dementia. Of relevance to this story is a recent report by Anne Cataldo et al. demonstrating that APP gene dosage modulates an AD
COMMENT Brain Aging and Age-Related Neurodegenerative Diseases: Are Vitamin and Trace-element Supplementation the "Miraculous" Solution? Alzheimer’s disease (AD) is a common and complex neurodegenerative disease that affects approximately 15 million peo
COMMENT Reply by Yong Shen I am glad Steve Barger brought up the controversy on whether ND-κB causes or counteracts apoptosis. This question in itself is interesting enough to attract more rigorous approaches for definitive study. Most of the studies that found N
COMMENT Tom Fagan has done a very nice job of calling our attention to these exceptionally important and concordant sets of results supporting Robin Holliday's original proposal for a role for epigenetic modifications in long- term memory (Holliday, 1999). R
COMMENT It would be good to see the response(s) of the authors. 0 Prof.Max
COMMENT What a great group of papers... From my perspective, the most thrilling paper is the one from Kevin McNaught and colleagues. It is important because it tests the idea that proteasome dysfunction is central to cell damage and inclusion formation in PD and
COMMENT Yong Shen should be congratulated on this comprehensive and interesting review; it contains several novel connections and ideas. However, I was somewhat disappointed by one passage. Despite a great deal of publication and discussion, misunderstandings abo
COMMENT A landmark paper demonstrating that APP intracellular domain is involved in transcriptional regulation. 0 dwalsh3
COMMENT The most innovative paper from 2001, which provided a novel means of modulating γ-secretase activity. 0 dwalsh3
COMMENT caspase-mediated cleavage of tau in AD? I would like to comment on this based on our report due out in JCI, but
COMMENT I agree with Troy that there may be different routes of anti-apoptotic mechanisms and neuronal apoptosis. The recent studies on caspase-mediated cleavage of MAP or tau are quite interesting. Troy, do you think this would be a normal physiological process
COMMENT Yong Shen does an excellent job of summarizing some of the important data supporting an important role for cell death in a number of neurodegenerative diseases. Clearly, there are a myriad of possible scenarios that may lead to neuronal cell death, and so
COMMENT Multiple lines of evidence have suggested that estrogen (and possibly androgens) protect against AD, although the mechanism(s) are unclear. Zhang et al. have used a well-defined model to look specifically at the effect of these steroid hormones on the neu
COMMENT Notch signaling plays a crucial role on cell fate specification during neuronal development in C. elegans, Drosophila and vertebrates. In the adult brain, however, the role of Notch signaling on neuronal morphology and function is largely unknown. Now, Wa
COMMENT Because the production of new neurons from stem cells occurs in the adult brain and may decline during normal aging (1), and in light of emerging evidence that neurogenesis may play an important role in learning and memory (2), it is important to understa
