Olle Kjellin on AD2000: donepezil in Alzheimer's disease.
COMMENT appreciate more comments by the experts on the AD2000 protocol in regard to all those quite long washout
11170 RESULTS
COMMENT appreciate more comments by the experts on the AD2000 protocol in regard to all those quite long washout
COMMENT Wow! lgnmatrix 0
COMMENT Additional insight on the role of statins in Alzheimer's is provided in the recent article by Rebeck and another by Koudinov and Koudinova, as well as in several articles listed at the Noteworthy collections of the Neurobiology of Lipids. postmaster
COMMENT Tobias is right, of course. It is only through formal experiment that one can test such specifics as dose and duration of treatment. The fact remains that the epi data gave the statins story a huge "shot in the arm," and the new data from the pr
COMMENT Epidemiological data are just one of the many things in the toolbox. Perfect as hypothesis factory, but then to be tested by entirely different methods. But do these and other statin-epi studies tell us whether to continue or discontinue therapeutic appro
COMMENT A point of clarification about my presentation: Prescribing bias could indeed account for some of the results in the Jick study, but Jick's design DID assure that statin exposures were antecedent to onset of clinical dementia. Thus, the timing issue
COMMENT I read Yong Shen's review on molecular events of neuron death in AD, and the comments, with
COMMENT Aβ has superoxide dismutase activity. Might Aβ synthesis be upregulated due to a compensatory reaction to reduced Cu,Zn-SOD activity? Kang (1) reports that methylglyoxal modifies Cu,Zn-SOD with a resultant loss of enzyme activity and copper leaving the pr
COMMENT In their recent article, Liu et al provided clear evidence that abnormal hyperphospharylation of tau protein may be induced by decreased 0-GlcNAcylation subsequent to a deficient glucose metabolism in Alzheimer disease (AD) brain. Experimentally, the auth
COMMENT I find this paper a significant contribution to the field, and one that will undoubtedly engender further work and exploration into potential new therapeutics. This is important for the Alzheimer's field because new approaches designed to increase ve
COMMENT comment by Dr. Ming Chen posted July 12 is somewhat misleading. Dr. Chen states that the “age-related
COMMENT nevertheless an important trial, as Lon Schneider says in his comment in Lancet. Even if it has methodological
COMMENT designed to show that donepezil is not worth the cost. Many people have commented on the methodological
COMMENT It's sad that pharma's hype about Alzheimer drugs leads families that cannot afford these top shelf drugs to feel so guilty. Patients know that a drug exists for their loved one and believe it would be negligent to withhold it. The industry prey
COMMENT Cortisol, I believe, inhibits BDNF expression or function. Fatty diet (low in Essential Fatty Acids-EFA) causes permanent stress in the offspring—with raised cortisol and homocysteine—when consumed in pregnancy. Fatty adult diet causes mitochondrial uncou