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Mary Reid on Transdifferentiation—Alive Again?

COMMENT Would there be room for the suggestion that AML stem cells may also migrate to the brain to form astrocytes? It seems of interest that Baldus et al(1) find overexpression of APP, ETS2 and ERG genes in AML. Wolvetang and colleagues (2)show that ETS2 transa

Maria Santos on ABAD, aka ERAB: Mitochondrial Miscreant Returns

COMMENT ABAD—The New/Old Good/Bad Guy in Alzheimer's Disease Lustbader and colleagues [1] present a complex potential mechanism for the role of amyloid β in Alzheimer's disease (AD) pathology. The authors created a crystal form of amyloid β-binding alco

Steven Greenberg on Anticoagulants for Alzheimer’s?

COMMENT The effects of unfractionated (Neurobiol Aging 2002;23:531) and now fractionated heparins on Aß bioactivity (in vitro) and deposition (in vivo) are clearly intriguing, though it remains unclear how to tie these in-vitro and in- vivo findings together. The

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