Carlos Saura on Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2.
COMMENT Feng et al. describe cortical degeneration in the forebrain of mice lacking the Alzheimer’s disease genes presenilin (PS) 1 and 2. The mice help to define essential roles of presenilins in the maintenance of brain function. These results confirm previous