11170 RESULTS
COMMENT This study demonstrates the effect of DHA on enhancing memory function. However, as I point out in this article, I thought two things should have been emphasized more and noted in the abstract, but weren't: 1) Soluble beta-amyloid had no reproducible
COMMENT While this paper is definitely of interest, I found some fault with their treatment of amyloid theory. The authors note in the abstract that they significnatly reduced "total amyloid," but they do not note that insoluble amyloid was not signific
COMMENT The nanoparticle gene transfer described by Bharali et al. is an exciting new avenue for genetic modification in the brain. The study suggests the organically modified nanoparticles are easy to make, are safe, and provide efficient and widespread transgen
COMMENT This paper was interesting, but I find several problems with it. First, there was no control group that was not immunized, and the rate of increase in antibody levels was not studied in the patients prior to baseline. Thus, since some patients had endogen
COMMENT Interesting piece of work. The more sophisticated these models are, the more you can conclude one way or another. Is this model suggesting to kill presenilin to cure AD? Of course not, but data are in favor of that. What if the explanation of the benefici
COMMENT The paper by Kang et al. is very interesting, both because it confirms the important role presenilins play in the activation of the PI3K/Akt pathway, and because it describes a novel role of PS2 in PDGF signaling. More important, for the mechanism involve
COMMENT This paper is one of the most interesting contributions of the year, and may well be one of the most informative animal models of AD yet published. To fully appreciate it, readers should first read two prior papers from this same group in which they syste
COMMENT This is a well-done paper; it emphasizes the need for meta-analyses to decipher relevant from irrelevant results in genetically complex diseases. Readers of this paper may also be interested in the continuously updated meta-analysis on the Alzforum's
COMMENT This, and other important work in a similar vein, suggests that "Alzheimerization" of brain occurs at least a decade prior to occurrence of symptoms. If clinically practical early markers for this process can be discovered, it would enable the i
COMMENT Will the real mechanism by which ApoE4 accelerates expression of AD please stand up? 0 john.breitner
COMMENT Another candidate explanation for the profound effect of APOE polymorphism on risk of AD. 0 john.breitner
COMMENT The authors of this paper make an important point in a very nice and elegant way. Glial progenitors require an additional signal to complete the process of myelination. They showed that a neurotrophin signal is what may be missing, as making a modified pr
COMMENT In their highly interesting paper, Kang and colleagues demonstrate an important additional role for the presenilins independent of their role in γ-secretase activity. This role is one of modulating several signal transduction pathways by influencing upstr
COMMENT This study is very interesting. It seems that increased Aβ may be directly involved in tau pathology due to the fact that it increases expression of c-Abl, which may phosphorylate tau. Zeng et al. (1) find that TopBP1 is a repressor of c-Abl expression. W
COMMENT other transmembrane proteins. I asked in one of my previous comments on this site: Who is keeping tally
