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Henry Paulson on A Step Toward Therapeutic RNA Interference

COMMENT Immediately following the description that RNA interference (RNAi) works in mammalian cells, it was recognized that such specific inhibitors of gene expression held tremendous potential as drugs (1). A wealth of papers describing the inhibition of disease

Mark Cookson on A Step Toward Therapeutic RNA Interference

COMMENT Many groups have adopted siRNA or shRNA technologies as the method of choice for gene knockdown since it was first demonstrated that these techniques work for mammalian cells. Although there are previous demonstrations that one can inject siRNA duplexes a

Thomas Gasser on PARK8 is Cloned: Introducing…"Dardarin"

COMMENT The identification of genes for Mendelian forms of Parkinson disease (PD) has greatly advanced the understanding of the molecular pathogenesis of this common neurodegenerative disorder. The discovery of mutations in the gene for α-synuclein (SNCA; PARK1)

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