11170 RESULTS
COMMENT my comments) have also found AD red blood cells to differ from controls. Certainly the Janoshazi et
COMMENT This correlation approach is mostly harmless, but the focus upon intellectual stimulation for purposes of prevention may have some long-term negative consequences. Not only is it somewhat misleading (the significance, based on big samples, having little i
COMMENT Zou et al. (1) report that γ-secretase is involved in the processing of megalin. In view of the fact that megalin binds cubilin, the receptor for B12-intrinsic factor complex, and mediates uptake of the vitamin B12-transcobalamin complex (2), what are the
COMMENT The observation of the relocalization of I2PPA2/SET/TAF-1 from the nucleus to the cytoplasm in AD neurons is of particular interest because of the possible role of this phosphatase inhibitor in the hyperphosphorylation of tau. Furthermore, we have recentl
COMMENT I believe these are potentially very significant findings. FNightingale512 0
COMMENT I must start by saying that it is quite gratifying that there has been such interest in our clinical trial (AD Cholesterol-Lowering Treatment—ADCLT trial; the Lipitor trial) (1). As the very first AD treatment trial testing a statin medication for clinica
COMMENT Aβ species, my comment is that HA administration, by changing the methylation status of membrane
COMMENT Homocysteine, oxidative stress, and AD: An even more vicious cycle! Commenting on Hasegawa et al.,
COMMENT The paper by Degterev et al. is a tour de force characterization of necroptosis, a non-apoptotic form of programmed cell death that involves necrosis and autophagy. Existence of this caspase-independent pathway was hypothesized from observations that seve
COMMENT very good 0 gdnfgdnf
COMMENT The main novel observation in this very exciting paper from Whitworth and colleagues is that there is a subtle loss of catecholaminergic neurons in parkin knockout flies. Mouse models have generally not found any loss of dopaminergic neurons, although a r
COMMENT Benjamin A. Samuels and Li-Huei Tsai Postsynaptic clusters of acetylcholine receptors (AChR) form at the developing neuromuscular junction (NMJ) prior to apposition by the presynaptic nerve terminal. Subsequently, clusters that are innervated by the nerve
COMMENT Homocysteine and AD: More Than Meets the Eye Hyoung-gon Lee, Mark A. Smith, Barney Dwyer, Aki Nunomura, George Perry, Xiongwei Zhu Increased levels of plasma homocysteine (HC), a key metabolic intermediate in sulfur amino acid metabolism, have been associ
COMMENT The results reported by Raphaelle Pardossi-Piquard and colleagues are most interesting and also provocative. The implication is that the amyloid peptides (any or all) exert a physiologic function (which I have not seen demonstrated), and that this functio
COMMENT I can't say that I agree with Paul Coleman's evaluation of this work. The method of analysis is quite convoluted, and it is not at all clear what is causing the difference in fluorescence intensity at particular wave lengths. It is very unlikely
