11174 RESULTS
COMMENT The report by Love and colleagues in Nature Medicine provides intriguing preliminary evidence for a biological effect of GDNF in humans with Parkinson disease. The greater area of staining for tyrosine hydroxylase in the striatum on the side previously mo
COMMENT I understand that further animal toxicity studies are in progress. However, over 100 patients have received intracerebral GDNF infusion by one route or another with no clinical toxicity and I can't believe that GDNF treatment won't be available
COMMENT Prion disorders include Creutzfeldt Jakob disease in humans, bovine spongiform encephalopathy in cattle, and chronic wasting disease in the deer and elk population of North America. The underlying pathogenic and infectious particle in all prion disorders
COMMENT DNA Fragmentation Mechanism Involving Oxidative Stress: Relevance to Alzheimer Disease While DNA strand breaks are stereotypical of an apoptotic program, their presence in Alzheimer disease (AD) is of such a widespread nature and numerically high scale (S
COMMENT Rubinsztein and colleagues present strong evidence that macroautophagic turnover of proteins requires dynein, possibly to transport autophagosomes and lysosomes into juxtaposition for fusion and initiation of digestion. This role of dynein may be especial
COMMENT The recent finding from Junn and the Mouradian group on DJ-1 interacting with Daxx is very interesting. First, by using the two hybridization system, Junn et al. found that DJ-1 can bind Daxx, which is a component of the Fas death receptor signal transduc
COMMENT Elena Cattaneo’s beautiful paper in Science (Zuccato et al., 2001) demonstrated clearly that in transfected cells and in transgenic animals, wild-type and mutant huntingtin modulate BDNF transcription in opposite directions. In conditionally immortalized
COMMENT Cortico-Cortical Connectivity: A Key Aspect to Neurodegeneration The work from William Yang and colleagues (Gu et al., 2005), while directed toward Huntington’s disease (HD), is likely broadly applicable to a number of neurodegenerative disorders includin
COMMENT Rosch and colleagues in the May 17 issue of PNAS provide intriguing new data implicating p75NTR in activity-dependent synaptic plasticity. The authors use two strains of p75NTR mutants (p75NTRexonIV-/- and p75NTRexonII-/-) to investigate the emerging conc
COMMENT The Wheel of Death: Neuronal Cell Cycle and Alzheimer Disease There are multiple unanswered questions related to the pathogenesis of Alzheimer disease (AD). However, a major step forward in answering at least three important aspects was recently provided
COMMENT The observation that DJ-1 is capable of protecting cells against oxidant-induced cell death has been confirmed in several laboratories without a very clear mechanism emerging for how this would happen. Showing that simple scavenging of radicals is not lik
COMMENT This mouse model seems to be a powerful tool to study different issues, the relationship between AD and lipids included. I am only surprised that cholesterol keeps being labelled as a risk factor for AD, despite the fact that in light of numerous old and
COMMENT This report by Vivian Budnik and coworkers provides some new insight into the normal roles of FasII, APPL and X11 in synapse formation, but it is especially interesting for AD researchers because of its potential insight into the mechanism of dystrophic n
COMMENT paper, the authors of the commented study at the first place, but also Drs. Koudinov and Koudinova, who
COMMENT I have a scientific question: How can aging be a risk factor for Alzheimer's? Diseases have causes, don't they? 1. Most aging humans don't get AD, and no wild animals, eating natural foods, get it, whatever their age. That includes chimps.
