11170 RESULTS
COMMENT The strength of this paper is the imaginative use of carefully crafted recombinant peptides to study a complicated process that is difficult to approach using conventional cell biological techniques. But one also has to keep in mind that no "native&q
COMMENT This is an excellent paper. Bart.DeStrooper 0
COMMENT Excellent article. FNightingale512 0
COMMENT Wu and colleagues, in a recent Nature Medicine paper, report a potential role for the MEOX2 hemeobox gene, also known as GAX, in Alzheimer disease. The authors cultured brain endothelial cells (BECs) from humans who died with Alzheimer disease, age-matche
COMMENT This paper will open a new kind of possible treatment. 0 zerreit
COMMENT This is a nice paper that, once more, implicates CBP-dependent transcription in the mechanism by which FAD mutants cause AD. 0 nikos.robakis
COMMENT This is an excellent study from the lab of Gang Yu, the original discoverer of nicastrin as a presenilin partner needed for γ-secretase activity when he was with Peter St. George-Hyslop in Toronto. In his new lab at UT Southwestern, Yu has nailed down an
COMMENT Prior to the 1980s, the cause of death of elderly demented individuals was commonly listed as pneumonia. In the 1980s, Alzheimer disease gained increasing attention, in part due to the tireless efforts of pathologists, such as Robert Terry, and neurologis
COMMENT This paper raises several provocative issues. It also lends further support to those who believe that the secondary function of telomeres is to serve as a checkpoint for uncontrolled cellular proliferation. This makes sense in tissues that continue to und
COMMENT This interesting paper corroborates the new concept that N-terminal truncated Aβ42 species are the seeds of amyloidosis, and a nice target for the vaccination approach. 0 andre.delacourte Truncated beta-amyloid peptide species in pre-clinical Alzheimer�
COMMENT This is the first paper to assess the potential overlap between PD and AD with respect to mutations in LRRK2. To more definitively exclude a role of LRRK2 in AD, more samples need to be screened, in particular those showing a familial aggregation of AD an
COMMENT Another Disconnect between Amyloid and Cognition Saura and colleagues (2005), like Van Leuven before (Dewachter et al., 2002), demonstrate a clear disconnect between amyloid-β and cognitive decline. As such, while it is clear that mutations in APP cause d
COMMENT This study provides more extensive and comprehensive analysis on the gene expression profile in human brains during aging. The authors show interesting data indicating that cerebellum ages less than cortex and that chimp cortex ages differently. The infor
COMMENT I think the new applications utilizing D15A looks very promising, but the nanotechnolgy has more broad-based, long-term implications. Showing no toxicity is an amazing leap forward as usually nanotech experiments show similar effects to silicosis. Perhaps
COMMENT I believe the bystander effect is heavily implicated here and anyone familiar with comments on
