11174 RESULTS
COMMENT The very interesting review of Dr. Vincent Marchesi deals with the notion that Aβ, once generated by diverse secretases, never leaves the membrane and exerts its toxicity by yet unknown mechanisms. Supporting this view, we and others have seen evidence th
COMMENT within vesicular compartments of the cell or at the plasma membrane. Finally, I conclude with a comment
COMMENT The very interesting review of Dr. Vincent Marchesi deals with the notion that Aβ, once generated by diverse secretases, never leaves the membrane and exerts its toxicity by yet unknown mechanisms. Supporting this view, we and others have seen evidence th
COMMENT within vesicular compartments of the cell or at the plasma membrane. Finally, I conclude with a comment
COMMENT Amyloid precursor protein (APP), a γ-secretase substrate, was thought to have a nuclear function in regulating Tip60-mediated transcription. In this paper, the authors unequivocally demonstrate that APP proteolysis, and therefore nuclear translocation, ha
COMMENT Exciting and novel. Will change the way we treat AD in the near future. 0 onthewebb
COMMENT Reply to Massimo Stefani by Brian Balin Dr. Stefani has responded to the background article with objections to arguments made in support of the pathogen hypothesis. While he admits that the microbial origin must be taken into consideration for some forms
COMMENT It is quite surprising that, despite a huge number of experiments done and papers published, the molecular events responsible for the Alzheimer's phenotype remain obscure. This article is a stimulating exercise that gives support to an alternative ex
COMMENT It is quite surprising that, despite a huge number of experiments done and papers published, the molecular events responsible for the Alzheimer's phenotype remain obscure. This article is a stimulating exercise that gives support to an alternative ex
COMMENT As is often the case, an outsider can give fresh perspectives in ways that someone from the inside has difficulty seeing. In this article, Dr. Vincent Marchesi, a former member of the Alzheimer Research Forum Advisory Board, presented a very thoughtful pe
COMMENT As is often the case, an outsider can give fresh perspectives in ways that someone from the inside has difficulty seeing. In this article, Dr. Vincent Marchesi, a former member of the Alzheimer Research Forum Advisory Board, presented a very thoughtful pe
COMMENT Brian Balin has written his Challenge so impressively, in particular stressing the insidious (though sporadic) nature of stealth microorganisms, that there is little to add except a few hopefully apposite points. Apropos of the extraordinary resistance of
COMMENT Is it possible that coronary artery bypass grafting was more likely complicated by atrial fibrillation requiring digoxin therapy in those who later developed AD? I refer to my previous post in which I ask whether digoxin therapy may be a risk factor for t
COMMENT This is an important study that confirms and extends prior chemical AD biomarker studies of CSF isoprostanes and tau while combining them with MRI to improve diagnosis of MCI. The work is significant because it bodes well for the success of the recently f
COMMENT These results fit well with the the tau/APP syngergy observed in the human brain (Delacourte et al., 2002). 0 andre.delacourte Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.
