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Guojun Bu on In Lipoparticles, ApoE Double Belt Keeps the Fat In

COMMENT As we explore the pathobiology of ApoE in AD and related dementias, there is an urgent need to understand the biochemical and biophysical properties of ApoE with the three main isoforms, ApoE2, ApoE3, and ApoE4 having differential effects on amyloids, cer

Olga Gursky on In Lipoparticles, ApoE Double Belt Keeps the Fat In

COMMENT This study uses antibody labeling and cryogenic electron microscopy to propose a model of lipidated apoE, the major functional form of this important apolipoprotein. Currently we have atomic structures of lipid-free, full-length modified human apoE and it

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