PAPER Oveisgharan S, Yu L, Capuano A, Arvanitakis Z, Barnes LL, Schneider JA, Bennett DA, Buchman AS
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Shane Liddelow, Philip Hasel on Squelching ApoE in Astrocytes of Tau-Ravaged Mice Dampens Degeneration
COMMENT This is an exciting set of data from the Holtzman group that adds another piece to the puzzle of APOE’s role as a risk factor for Alzheimer’s Disease (AD). In this paper, Wang et al. use the P301S mouse model of AD, expressing either ApoE3 or ApoE4, and g
Andra Elena
PSEN1 I168dup
MUTATIONS PSEN1 73653584_73653585 GRCh37/hg19--- ATA Exon 6 Duplicaton Coding Unknown, but in silico algorithms (PROVEAN and SIFT) predicted pathogenicity and CADD score was 20.2. Neuropatholgoy consistent with AD in one case. I168dup Alzheimer's Disease: Not
Evelyn Neil
National Institutes of HealthBethesda, United States
Elena Galea on Squelching ApoE in Astrocytes of Tau-Ravaged Mice Dampens Degeneration
COMMENT Two comments: 1) This study, however impressive, has a limitation: There is no Aβ pathology. Aβ uptake by astrocytes damages their endolysosomal system (Sanchez-Mico et al., 2021). Thus, the question is: How would astrocytes damaged by Aβ respond to Tau p
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