PAPER Koire A, Katsonis P, Lichtarge O

REPURPOSING GERMLINE EXOMES OF THE CANCER GENOME ATLAS DEMANDS A CAUTIOUS APPROACH AND SAMPLE-SPECIFIC VARIANT FILTERING.

Pac Symp Biocomput. 2016;21:207-18. PubMed: 26776187

Olivier Lichtarge

Baylor College of Medicine
Houston

Rebecca Gillani on Does Calcium Overload Mark Dendritic Spines for Destruction?

COMMENT This study tackles one of the biggest challenges in treating people living with multiple sclerosis (MS), which is our limited ability to slow disability accumulation in progressive MS. Despite an immense effort, treatment options for progressive MS are li

Carsten Korth, Andreas Müller-Schiffmann on New Data Questions Herpes-Alzheimer’s Connection

COMMENT Schnier et al. present a new, impressive epidemiological analysis in four large European cohorts to investigate a potential association of herpesvirus infection with the later development of dementia. Results from this study are, as previous ones, equivoc

Rebecca Gillani

Massachusetts General Hospital, Harvard Medical School
Boston, United States

Grace Stutzmann on Does Calcium Overload Mark Dendritic Spines for Destruction?

COMMENT This study strings together a series of enlightening and novel observations regarding cortical synapse decline in a model of cortical multiple sclerosis (c-MS), and aligns excitatory synapse loss, increased calcium load in dendrites and spines, phagocyte

Colin Masters on New Data Question Anti-Microbial Powers of Aβ

COMMENT To date, I’m not convinced by any of the experimental or clinical evidence that a conventional virus underlies the pathogenesis of AD. Latent or temperate conventional viral activity may, however, play a role in the relatively common phenocopy of AD, mark

William Eimer, Rudy Tanzi on New Data Question Anti-Microbial Powers of Aβ

COMMENT Bocharova et al. tested 5XFAD mice in an attempt to replicate our results demonstrating a protective role of Aβ against HSV1 (Eimer et al., 2018). Bocharova et al. present data intended to suggest the contrary; however, we do not believe their data consti

Richard Lathe on New Data Question Anti-Microbial Powers of Aβ

COMMENT Bocharova et al. present an interesting perspective on the role of Aβ as an antimicrobial peptide. Rob Moir and colleagues had reported earlier that Aβ has antimicrobial activity in vitro against bacteria and yeast (Soscia et al., 2010), agglutinates Cand

PAPER Kastrukoff LF, Lau AS, Thomas EE

The effect of mouse strain on herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS).

Herpesviridae. 2012 Mar 26;3:4. PubMed: 22449238

Adam Suhy

Washington University School of Medicine
Saint Louis, United States

PAPER Geurs TL, Hill EB, Lippold DM, French AR

Sex differences in murine susceptibility to systemic viral infections.

J Autoimmun. 2012 May;38(2-3):J245-53. Epub 2011 Dec 29 PubMed: 22209097

Nagendran Ramalingam

Brigham & Women's Hospital/Harvard Medical School
Boston, United States

Charles Stromeyer on Does Calcium Overload Mark Dendritic Spines for Destruction?

COMMENT This interesting work raises questions such as how does the immune system surveil the CNS? One answer comes from a new paper in Cell led by Jonathan Kipnis, which shows immune cells in the meninge. When they study an MS mouse model, they find activated im

PAPER Rustenhoven J, Drieu A, Mamuladze T, de Lima KA, Dykstra T, Wall M, Papadopoulos Z, Kanamori M, Salvador AF, Baker W, Lemieux M, Da Mesquita S, Cugurra A, Fitzpatrick J, Sviben S, Kossina R, Bayguinov P, Townsend RR, Zhang Q, Erdmann-Gilmore P, Smirnov I, Lopes MB, Herz J, Kipnis J

Functional characterization of the dural sinuses as a neuroimmune interface.

Cell. 2021 Jan 18; PubMed: 33508229