PAPER The Lancet Neurology

Rapid drug access and scientific rigour: a delicate balance.

Lancet Neurol. 2021 Jan;20(1):1. PubMed: 33340471

PAPER Kapurniotu A

Enlightening amyloid fibrils linked to type 2 diabetes and cross-interactions with Aβ.

Nat Struct Mol Biol. 2020 Nov;27(11):1006-1008. PubMed: 33097922

PAPER Chen CL, Hsu MH, Hung CH, Chiu PY, Liu CH

Prevalence and Associated Factors of Visual Hallucinations in Patients with Vascular Cognitive Impairment.

Behav Neurol. 2021;2021:8866763. Epub 2021 Jan 9 PubMed: 33505534

PAPER Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D

A growth-factor-activated lysosomal K+ channel regulates Parkinson's pathology.

Nature. 2021 Mar;591(7850):431-437. Epub 2021 Jan 27 PubMed: 33505021

Takahisa Kanekiyo on APOE Tied to Increased Susceptibility to SARS-CoV-2

COMMENT This is an interesting paper by Wang et al. showing that APOE4 is a genetic modifier facilitating the direct infection of SARS-CoV-2 in human iPSC-derived neurons and astrocytes. I was surprised by this. Future studies should define if APOE4 causes this p

Timothy Daly, Stéphane Epelbaum on Dementia Researchers Commend FDA Crackdown on Supplement Hype

COMMENT The history of Alzheimer’s Disease research demonstrates that getting a validated drug to market is incredibly difficult. So it is not surprising that all sorts of claims are made about alternatives, the “supplement hype” described here being one of them.

Does Calcium Overload Mark Dendritic Spines for Destruction?

RESEARCH NEWS 2021-01-29 Research News Bouts of white-matter destruction in the brain and spinal cord are a hallmark of multiple sclerosis, but the inflammatory disease also ravages gray matter. Using a mouse model of cortical MS, researchers led by Doron Merkler at the Universit

APOE Tied to Increased Susceptibility to SARS-CoV-2

RESEARCH NEWS 2021-01-29 Research News Part 2 of a two-part series. Click here for Part 1. It turns out a person’s risk associated with ApoE4 goes beyond Alzheimer’s and vascular disease. This apolipoprotein allele can also worsen infections caused by certain viruses. One of thos

PAPER Moriarty PM, Gorby LK, Stroes ES, Kastelein JP, Davidson M, Tsimikas S

Lipoprotein(a) and Its Potential Association with Thrombosis and Inflammation in COVID-19: a Testable Hypothesis.

Curr Atheroscler Rep. 2020 Jul 25;22(9):48. PubMed: 32710255

PAPER Inal J

Biological Factors Linking ApoE ε4 Variant and Severe COVID-19.

Curr Atheroscler Rep. 2020 Oct 2;22(11):70. PubMed: 33006059

PAPER Daniloski Z, Jordan TX, Wessels HH, Hoagland DA, Kasela S, Legut M, Maniatis S, Mimitou EP, Lu L, Geller E, Danziger O, Rosenberg BR, Phatnani H, Smibert P, Lappalainen T, tenOever BR, Sanjana NE

Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.

Cell. 2021 Jan 7;184(1):92-105.e16. Epub 2020 Oct 24 PubMed: 33147445

PAPER Potokar M, Jorgačevski J, Zorec R

Astrocytes in Flavivirus Infections.

Int J Mol Sci. 2019 Feb 6;20(3) PubMed: 30736273

PAPER Soung A, Klein RS

Viral Encephalitis and Neurologic Diseases: Focus on Astrocytes.

Trends Mol Med. 2018 Nov;24(11):950-962. Epub 2018 Oct 9 PubMed: 30314877

PAPER Martin GM

APOE alleles and lipophylic pathogens.

Neurobiol Aging. 1999 Jul-Aug;20(4):441-3. PubMed: 10604437

PAPER Sing CF, Davignon J

Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation.

Am J Hum Genet. 1985 Mar;37(2):268-85. PubMed: 3985008