THERAPEUTICS Eisai Co., Ltd. Immunotherapy (passive) Tau In December 2019, Eisai began a Phase 1 trial testing the safety and tolerability of a single intravenous infusion in healthy adults. Secondary outcomes included serum and CSF pharmacokinetics and immunogenicity ...
Jacek Biernat, Senthilvelrajan Kaniyappan, Eckhard Mandelkow on Mounting Modifications Move Tau Toward Aggregation in Alzheimer’s Brain
COMMENT This paper represents a major advance in the understanding of molecular changes in neuronal tau protein during the progression of Alzheimer‘s disease. This was made possible in large part by advances in mass spectroscopy methods, making use of calibration ...
PAPER Wang Y, Zhang Y, Hu W, Xie S, Gong CX, Iqbal K, Liu F
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PAPER Ksiezak-Reding H, Liu WK, Yen SH1472994
PAPER Kenessey A, Yen SH
The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments.Brain Res. 1993 Nov 26;629(1):40-6. PubMed: 8287279
PAPER Gärtner U, Janke C, Holzer M, Vanmechelen E, Arendt T10192212
Boston Children's Hospital/Harvard Medical SchoolBoston, United States
COMMENT The authors provide important findings that may help to answer some current uncertainties, as well as guide future consideration of this or a similar class of compounds: Mechanism-based versus compound-based. Although both compounds share similarities, ...
PAPER Kopyov A, Uhlendorf TL, Cohen RW33318432
PAPER Crispi S, Filosa S33318431
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PAPER Vilasboas-Campos D, Costa MD, Teixeira-Castro A, Rios R, Silva FG, Aierken A, Zhang X, Bessa C, Dias AC, Maciel P
Data on the effects of Hyptis spp. and Lycium spp. plant extracts in C. elegans models of genetically determined neurodegenerative diseases.Data Brief. 2020 Dec;33:106598. Epub 2020 Nov 28 PubMed: 33318982
PAPER Ren X, Butterfield DA