PAPER Adani G, Filippini T, Garuti C, Malavolti M, Vinceti G, Zamboni G, Tondelli M, Galli C, Costa M, Vinceti M, Chiari A
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1413 RESULTS
PAPER Groot C, Doré V, Robertson J, Burnham SC, Savage G, Ossenkoppele R, Rowe CC, Villemagne VL
Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β-negative cognitively normal individuals.
Neurobiol Aging. 2021 Jan;97:41-48. Epub 2020 Oct 1 PubMed: 33130455PAPER Abate G, Vezzoli M, Sandri M, Rungratanawanich W, Memo M, Uberti D
Mitochondria and cellular redox state on the route from ageing to Alzheimer's disease.
Mech Ageing Dev. 2020 Dec;192:111385. Epub 2020 Oct 28 PubMed: 33129798PAPER Foster CM, Kennedy KM, Daugherty AM, Rodrigue KM
Contribution of iron and Aβ to age differences in entorhinal and hippocampal subfield volume.
Neurology. 2020 Nov 3;95(18):e2586-e2594. Epub 2020 Sep 16 PubMed: 32938781PAPER Jester DJ, Andel R, Cechová K, Laczó J, Lerch O, Marková H, Nikolai T, Vyhnálek M, Hort J
Cognitive Phenotypes of Older Adults with Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment: The Czech Brain Aging Study.
J Int Neuropsychol Soc. 2021 Apr;27(4):329-342. Epub 2020 Nov 3 PubMed: 33138890PAPER Qu W, Li L
Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice.
J Neurosci. 2020 Dec 9;40(50):9552-9563. Epub 2020 Nov 2 PubMed: 33139402PAPER Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, Younkin SG, Graff-Radford NR, Wszolek ZK, Brafman DA, Asmann YW, Ertekin-Taner N, Kanekiyo T, Bu G
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
Nat Commun. 2020 Nov 2;11(1):5540. PubMed: 33139712PSEN2 R284G
MUTATIONS PSEN2 227077798 GRCh37/hg19 rs1208742830 A G Exon 9 Point, Missense Coding Increased Aβ42 and Aβ42/Aβ40 in a cell assay. Unknown. R284G Alzheimer's Disease: Likely Pathogenic This variant was originally identified in a screen of patients with early o
PSEN1 G378R
MUTATIONS PSEN1 73683836 GRCh37/hg19 G C Exon 11 Point, Missense Coding Unknown, but predicted deleterious in silico and two other pathogenic mutations in same residue. Unknown, but MRI of one patient showed fronto-temporo-parietal atrophy and CSF biomarkers consis
PSEN2 S236S
MUTATIONS PSEN2 227076671 GRCh37/hg19 rs61730652 T C Exon 8 Point, Silent Coding Unknown. In silico analyis predicted it is benign (PHRED-scaled CADD = 7.2), but could alter splicing. Unknown, but in one patient PET showed amyloid deposition and MRI revealed atroph
PAPER Kalogeropulou AF, Freemantle JB, Lis P, Vides EG, Polinski NK, Alessi DR
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.
Biochem J. 2020 Nov 27;477(22):4397-4423. PubMed: 33135724PAPER Di Natale C, Natale CF, Florio D, Netti PA, Morelli G, Ventre M, Marasco D
Effects of surface nanopatterning on internalization and amyloid aggregation of the fragment 264-277 of Nucleophosmin 1.
Colloids Surf B Biointerfaces. 2021 Jan;197:111439. Epub 2020 Oct 26 PubMed: 33137636PAPER Lee R, Lee NE, Choi SH, Nam SM, Kim HC, Rhim H, Cho IH, Hwang SH, Nah SY
Effects of gintonin-enriched fraction on hippocampal gene expressions.
Integr Med Res. 2021 Jun;10(2):100475. Epub 2020 Jul 15 PubMed: 33134079PAPER Jurkowski MP, Bettio L, K Woo E, Patten A, Yau SY, Gil-Mohapel J
Beyond the Hippocampus and the SVZ: Adult Neurogenesis Throughout the Brain.
Front Cell Neurosci. 2020;14:576444. Epub 2020 Sep 29 PubMed: 33132848PAPER Pantelopulos GA, Panahi A, Straub JE
Impact of Cholesterol Concentration and Lipid Phase on Structure and Fluctuation of Amyloid Precursor Protein.
J Phys Chem B. 2020 Nov 12;124(45):10173-10185. Epub 2020 Nov 2 PubMed: 33135883Current Filters
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