Kiyoaki Kobayashi

Eisai
Tokyo, Japan

PAPER Soto-Mercado V, Mendivil-Perez M, Jimenez-Del-Rio M, Velez-Pardo C

Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer's Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB1 Receptor.

J Alzheimers Dis. 2020 Nov 23; PubMed: 33252082

John Tiernan

Huber Heights, United States

Philip Scheltens, Everard (Jort) Vijverberg on Aducanumab Still Needs to Prove Itself, Researchers Say

COMMENT Much has been said on aducanumab already and, as in any scientific debate, opinions differ widely. Unfortunately, as was evident from the FDA hearing, the debate has become polarized, as if it were politics. This is never beneficial to any debate. This sc

PSEN2 P287P

MUTATIONS PSEN2 227077809 GRCh37/hg19 rs75733498 C T Exon 9 Point, Silent Coding Unknown, but in silico analysis did not predict a damaging effect (PHRED-scaled CADD = 11.4). Unknown, but associated with increased glucose metabolism in the bilateral fronto-temporo-

PSEN1 c.*947G> A

MUTATIONS PSEN1 73686944 GRCh37/hg19 rs7523 G A Exon 12, 3' UTR Point Non-Coding Unknown Unknown, associated with increased thickness in the inferior frontal and orbitofrontal cortices, and basal ganglia c.*947G>A Alzheimer's Disease: Benign This commo

Everard (Jort) Vijverberg

Amsterdam UMC Dept. of Neurology/Alzheimer Center and Brain Research Center Amsterdam

David Curtis

London, United Kingdom

Minnie Cooper

PAPER Malik N, Kornelsen R, McCormick S, Colpo N, Merkens H, Bendre S, Benard F, Sossi V, Schirrmacher R, Schaffer P

Development and biological evaluation of[18F]FMN3PA & [18F]FMN3PU for leucine-rich repeat kinase 2 (LRRK2) in vivo PET imaging.

Eur J Med Chem. 2021 Feb 5;211:113005. Epub 2020 Nov 11 PubMed: 33248850

PAPER Senkevich K, Bandres-Ciga S, Gan-Or Z, Krohn L, International Parkinson's Disease Genomics Consortium (IPDGC)

Lack of evidence for association of UQCRC1 with Parkinson's disease in Europeans.

Neurobiol Aging. 2021 May;101:297.e1-297.e4. Epub 2020 Nov 2 PubMed: 33248804

PAPER Kong G, Ellul S, Narayana VK, Kanojia K, Ha HT, Li S, Renoir T, Cao KL, Hannan AJ

An integrated metagenomics and metabolomics approach implicates the microbiota-gut-brain axis in the pathogenesis of Huntington's disease.

Neurobiol Dis. 2021 Jan;148:105199. Epub 2020 Nov 26 PubMed: 33249136

PAPER Robbins R, DiClemente RJ, Troxel AB, Jean-Louis G, Butler M, Rapoport DM, Czeisler CA

Sleep medication use and incident dementia in a nationally representative sample of older adults in the US.

Sleep Med. 2021 Mar;79:183-189. Epub 2020 Nov 11 PubMed: 33248901

PAPER Chowdhury S, Kumar S

Inhibition of BACE1, MAO-B, cholinesterase enzymes, and anti-amyloidogenic potential of selected natural phytoconstituents: Multi-target-directed ligand approach.

J Food Biochem. 2021 Jan;45(1):e13571. Epub 2020 Nov 29 PubMed: 33249607

PAPER Hansson O, Cullen N, Zetterberg H, Alzheimer’s Disease Neuroimaging Initiative, Blennow K, Mattsson-Carlgren N

Plasma phosphorylated tau181 and neurodegeneration in Alzheimer's disease.

Ann Clin Transl Neurol. 2021 Jan;8(1):259-265. Epub 2020 Nov 29 PubMed: 33249783