Ashir Mehta

Barbara Bendlin on Not Just a Biomarker: YKL-40 Links Glial Clock to Amyloidosis

COMMENT YKL-40 has been measured in CSF in the context of neurodegenerative disease for several years and is typically considered an indicator of activated astrocytes. Here, through a comprehensive series of experiments, the Musiek lab and collaborators provide f

Mohammad Ansari

Michael Ewers on In People Who Defy ApoE, New Alzheimer’s Risk Genes Found

COMMENT This is an elegant study by Kim and colleagues harnessing the gain in statistical power by virtue of focusing on the genetic variants that modify the risk of ApoE e4 genotype based on exome-sequencing data and using the evolutionary-action approach, i.e.,

In People Who Defy ApoE, New Alzheimer’s Risk Genes Found

RESEARCH NEWS 2020-12-29 Research News ApoE2 lowers Alzheimer’s risk; ApoE4 raises it. But what explains the people who buck this trend—i.e., the ApoE2 carriers who get AD, and ApoE4 carriers who stay free of it into old age? In the December 7 Alzheimer’s and Dementia, researcher