RESEARCH NEWS 2021-01-15 Research News Aggregated tau can be passed between cells in tiny vesicles known as exosomes. Once these lipid bubbles are inside a new cell, how does tau escape them? In the January 8 Acta Neuropathologica, researchers led by Jürgen Götz at the University ...
PAPER Skotland T, Sandvig K, Llorente A28342835
PAPER Zaborowski MP, Balaj L, Breakefield XO, Lai CP26955082
PAPER Neff RA, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song WM, Li A, Castranio EL, Tcw J, Ho L, Goate A, Fossati V, Noggle S, Gandy S, Ehrlich ME, Katsel P, Schadt E, Cai D, Brennand KJ, Haroutunian V, Zhang B
Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets.Sci Adv. 2021 Jan;7(2) Print 2021 Jan PubMed: 33523961
COMMENT In my opinion, this is the clearest indication that Alzheimer's disease is not a single entity, despite the ubiquity of amyloid plaques, and should not be treated as one. Therapies that seek to slow progression of dementia are unlikely to be ...
Pieter Jelle Visser, Betty Tijms on Expression Analysis Uncovers Three Distinct Forms of Alzheimer’s
COMMENT Biological heterogeneity of Alzheimer’s disease is a relatively unexplored territory, even though there is ample evidence based on clinical and imaging studies that heterogeneity does exist. Here, Neff and colleagues explored heterogeneity in gene ...
Mayo ClinicJacksonville, United States
Greensboro, United States
Bial BiotechBrookline, United States
COMMENT Kim et al. applied an elegant evolution-based variant functional impact weighting method and a novel discordant phenotype subsampling approach to identify genes that modify predicted AD outcomes in APOE-ε4 and ε2 carriers. Their analyses suggest ...
PAPER Kawada T33439391
PAPER Lyu Z, Zheng S, Zhang X, Mai Y, Pan J, Hummel T, Hähner A, Zou L
Olfactory impairment as an early marker of Parkinson's disease in REM sleep behaviour disorder: a systematic review and meta-analysis.J Neurol Neurosurg Psychiatry. 2021 Mar;92(3):271-281. Epub 2021 Jan 12 PubMed: 33436502