PAPER Sakuwa M, Adachi T, Yoshida K, Adachi Y, Nakano T, Hanajima R

An autopsy case of PARK2 due to a homozygous exon 2 deletion of parkin and associated with α-synucleinopathy.

Neuropathology. 2021 Aug;41(4):293-300. Epub 2021 Jun 13 PubMed: 34121225

PAPER Emwas AH, Alghrably M, Dhahri M, Sharfalddin A, Alsiary R, Jaremko M, Faa G, Campagna M, Congiu T, Piras M, Piludu M, Pichiri G, Coni P, Lachowicz JI

Living with the enemy: from protein-misfolding pathologies we know, to those we want to know.

Ageing Res Rev. 2021 Sep;70:101391. Epub 2021 Jun 11 PubMed: 34119687

PAPER Mazzocchi M, Goulding SR, Wyatt SL, Collins LM, Sullivan AM, O'Keeffe GW

LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and α-synuclein-induced degeneration in cellular models of Parkinson's disease.

Mol Cell Neurosci. 2021 Sep;115:103642. Epub 2021 Jun 10 PubMed: 34119632

PAPER Riley JF, Fioramonti PJ, Rusnock AK, Hehnly H, Castañeda CA

ALS-linked mutations impair UBQLN2 stress-induced biomolecular condensate assembly in cells.

J Neurochem. 2021 Oct;159(1):145-155. Epub 2021 Aug 20 PubMed: 34129687

PAPER Ni J, Liu Z, Yuan Y, Li W, Hu Y, Liu P, Hou X, Zhu X, Tang X, Liang M, Zheng S, Hou X, Du J, Tang J, Jiang H, Shen L, Tang B, Wang J

Mitochondrial genome variations are associated with amyotrophic lateral sclerosis in patients from mainland China.

J Neurol. 2021 Jun 15; PubMed: 34129120

PAPER Catanese A, Rajkumar S, Sommer D, Freisem D, Wirth A, Aly A, Massa-López D, Olivieri A, Torelli F, Ioannidis V, Lipecka J, Guerrera IC, Zytnicki D, Ludolph A, Kabashi E, Mulaw MA, Roselli F, Böckers TM

Synaptic disruption and CREB-regulated transcription are restored by K+ channel blockers in ALS.

EMBO Mol Med. 2021 Jul 7;13(7):e13131. Epub 2021 Jun 14 PubMed: 34125498

PAPER Zhu FD, Hu YJ, Yu L, Zhou XG, Wu JM, Tang Y, Qin DL, Fan QZ, Wu AG

Nanoparticles: A Hope for the Treatment of Inflammation in CNS.

Front Pharmacol. 2021;12:683935. Epub 2021 May 26 PubMed: 34122112

PAPER Beswick E, Forbes D, Hassan Z, Wong C, Newton J, Carson A, Abrahams S, Chandran S, Pal S

A systematic review of non-motor symptom evaluation in clinical trials for amyotrophic lateral sclerosis.

J Neurol. 2021 Jun 13; PubMed: 34120226

PAPER Sarraf P, Bitarafan S, Nafissi S, Fathi D, Abaj F, Asl Motallebnejad Z, Teimouri R, Vahedi K

The correlation of the serum level of L-carnitine with disease severity in patients with Amyotrophic lateral sclerosis.

J Clin Neurosci. 2021 Jul;89:232-236. Epub 2021 May 13 PubMed: 34119273

PAPER Gelisse P, Crespel A, Luigi Gigli G, Kaplan PW

Stimulus-Induced Rhythmic or Periodic Intermittent Discharges (SIRPIDs) in patients with triphasic waves and Creutzfeldt-Jakob disease.

Clin Neurophysiol. 2021 Aug;132(8):1757-1769. Epub 2021 May 20 PubMed: 34130242

PAPER Molęda Z, Zawadzka A, Czarnocki Z, Monjas L, Hirsch AK, Budzianowski A, Maurin JK

"Clicking" fragment leads to novel dual-binding cholinesterase inhibitors.

Bioorg Med Chem. 2021 Jul 15;42:116269. Epub 2021 Jun 7 PubMed: 34130217

PAPER Ferreira D, Nedelska Z, Graff-Radford J, Przybelski SA, Lesnick TG, Schwarz CG, Botha H, Senjem ML, Fields JA, Knopman DS, Savica R, Ferman TJ, Graff-Radford NR, Lowe VJ, Jack CR, Petersen RC, Lemstra AW, van de Beek M, Barkhof F, Blanc F, Loureiro de Sousa P, Philippi N, Cretin B, Demuynck C, Hort J, Oppedal K, Boeve BF, Aarsland D, Westman E, Kantarci K

Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies.

Neurobiol Aging. 2021 Sep;105:252-261. Epub 2021 May 14 PubMed: 34130107

PAPER Tadokoro K, Yamashita T, Fukui Y, Nomura E, Ohta Y, Ueno S, Nishina S, Tsunoda K, Wakutani Y, Takao Y, Miyoshi T, Higashi Y, Osakada Y, Sasaki R, Matsumoto N, Kawahara Y, Omote Y, Takemoto M, Hishikawa N, Morihara R, Abe K

Early detection of cognitive decline in mild cognitive impairment and Alzheimer's disease with a novel eye tracking test.

J Neurol Sci. 2021 Aug 15;427:117529. Epub 2021 Jun 3 PubMed: 34130064

PAPER Bergström S, Remnestål J, Yousef J, Olofsson J, Markaki I, Carvalho S, Corvol JC, Kultima K, Kilander L, Löwenmark M, Ingelsson M, Blennow K, Zetterberg H, Nellgård B, Brosseron F, Heneka MT, Bosch B, Sanchez-Valle R, Månberg A, Svenningsson P, Nilsson P

Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.

Ann Clin Transl Neurol. 2021 Jul;8(7):1456-1470. Epub 2021 Jun 15 PubMed: 34129723

PAPER Triunfol M, Gouveia FC

What's not in the news headlines or titles of Alzheimer disease articles? #InMice.

PLoS Biol. 2021 Jun;19(6):e3001260. Epub 2021 Jun 15 PubMed: 34129637