Sans C9ORF72, Microglia Devour More Aβ Plaques. Synapses, Too.

RESEARCH NEWS 2021-06-18 Research News Hexanucleotide expansions within intron 1 of the C9ORF72 gene not only lead to the production of toxic products; they also douse the normal expression of the gene. The consequences of this loss play out dramatically within microglia, accordi

Proteostasis Consortium Seminars- Aggresomes: a Non-Universal Program for Maintaining Proteostasis

CONFERENCE 2021-08-11 00:00:00-2021-08-11 00:00:00 Webinar 11 August 2021 Organizers: The Proteostasis Consortium led by Richard Morimoto, Ph.D., Northwestern University Speaker: Darcie Moore, University of Wisconsin, Madison Meeting time: 12 PM EST View Conference Website 0

Proteostasis Consortium Seminars- Sorting it Out: Understanding AD Genetic Risk and Endocytic Network Trafficking Using Human Neuronal Models

CONFERENCE 2021-08-04 00:00:00-2021-08-04 00:00:00 Webinar 04 August 2021 Organizers: The Proteostasis Consortium led by Richard Morimoto, Ph.D., Northwestern University Speaker: Jessica Young, University of Washington Meeting time: 12 PM EST   View Conference Website 0

PAPER Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AK, Shelest O, Landeros J, Vazquez M, Kim J, Ghaffari L, O'Rourke JG, Geschwind DH, Blurton-Jones M, Holtzman DM, Sattler R, Baloh RH

C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.

Neuron. 2021 Jul 21;109(14):2275-2291.e8. Epub 2021 Jun 15 PubMed: 34133945

Diana Svaldi

Eli Lilly and Company
Westfield, United States

Natalia Valle

Sant Pau Biomedical Research Institute, Memory Unit
Barcelona, Spain

Laura Parnas

United States

Min Shi, Tessandra Stewart, Jing Zhang on Neuronal Exosomes Embroiled in Controversy

COMMENT The recent publication by Norman et al. suggests that L1CAM is not associated with extracellular vesicles (EVs) in human cerebrospinal fluid (CSF) or plasma; however, the conclusion contrasts sharply with a large body of evidence that already exists in th

PAPER Kenwrick S, Watkins A, De Angelis E

Neural cell recognition molecule L1: relating biological complexity to human disease mutations.

Hum Mol Genet. 2000 Apr 12;9(6):879-86. PubMed: 10767310

Mayra Fernandez

United States

Rabia Duran

PAPER van der Wildt B, Nezam M, Kooijman EJ, Reyes ST, Shen B, Windhorst AD, Chin FT

Evaluation of carbon-11 labeled 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide as PET tracer for imaging of CSF-1R expression in the brain.

Bioorg Med Chem. 2021 Jul 15;42:116245. Epub 2021 May 30 PubMed: 34119698

PAPER Yang Y, Ye C, Sun J, Liang L, Lv H, Gao L, Fang J, Ma T, Wu T

Alteration of brain structural connectivity in progression of Parkinson's disease: A connectome-wide network analysis.

Neuroimage Clin. 2021;31:102715. Epub 2021 Jun 6 PubMed: 34130192

PAPER Ma KY, Fokkens MR, Reggiori F, Mari M, Verbeek DS

Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy.

Transl Neurodegener. 2021 Jun 15;10(1):19. PubMed: 34127073

PAPER Park SH, Nam GE, Han K, Huh Y, Kim W, Lee MK, Koh ES, Kim ES, Kim MK, Kwon HS, Kim SM, Cho KH, Park YG

Association of Dynamic Changes in Metabolic Syndrome Status with the Risk of Parkinson's Disease: A Nationwide Cohort Study.

J Parkinsons Dis. 2021;11(4):1751-1759. PubMed: 34120914