PAPER Song D, Yu DS, Sun Q, He G

Correlates of Sleep Disturbance among Older Adults with Mild Cognitive Impairment: A Cross-Sectional Study.

Int J Environ Res Public Health. 2020 Jul 6;17(13) PubMed: 32640633

Wim Annaert on γ-Secretase Spotted Traveling Solo or in Pairs, Not in Big Groups

COMMENT Of note, our study focused on the distribution of γ-sec specifically at the cell surface. This should be the site where both ADAM-10 shedding and intramembrane proteolysis by γ-sec preferentially occurs, whereas for BACE1 and γ-sec this should be endosoma

Patrick Fraering on γ-Secretase Spotted Traveling Solo or in Pairs, Not in Big Groups

COMMENT This is an interesting, very well conducted, and solid study using super-resolution microscopy to visualize the spatial and regional distribution and dynamics of individual γ-secretase particles in membranes of living fibroblasts. This challenging task co

γ-Secretase Spotted Traveling Solo or in Pairs, Not in Big Groups

RESEARCH NEWS 2020-07-10 Research News CryoEM of frozen membranes has revealed its most intimate folds. Biochemistry of tissue extracts says it bundles up with other secretases. But how does γ-secretase, the all-important enzyme that cleaves Aβ42 from its precursor, truly behave

Lei Liu, Dennis Selkoe on γ-Secretase Spotted Traveling Solo or in Pairs, Not in Big Groups

COMMENT In our 2015 (Chen et al., 2015) and 2019 (Liu et al., 2019) studies, we biochemically isolated protein complexes (roughly >5 MDa) that contain the four γ-secretase complex components and ADAM10/17 or BACE1. Furthermore, in our 2019 study, we confirmed

PET Tracer PI-2620 Detects 4R Tau Deposits

RESEARCH NEWS 2020-07-10 Research News Tau tracers have invigorated Alzheimer’s research, but they initially proved disappointing for other tauopathies. That is now changing, with at least two tracers, PI-2620 and APN-1607, that appear to bind specifically to the 4R tau deposits

Yunxiao Wang

PAPER Brendel M, Barthel H, van Eimeren T, Marek K, Beyer L, Song M, Palleis C, Gehmeyr M, Fietzek U, Respondek G, Sauerbeck J, Nitschmann A, Zach C, Hammes J, Barbe MT, Onur O, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Barret O, Madonia J, Russell DS, Stephens A, Roeber S, Herms J, Bötzel K, Classen J, Bartenstein P, Villemagne V, Levin J, Höglinger GU, Drzezga A, Seibyl J, Sabri O

Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy.

JAMA Neurol. 2020 Nov 1;77(11):1408-1419. PubMed: 33165511

Liver Enzyme Levitates with Exercise, Spurs Learning in Old Mice

RESEARCH NEWS 2020-07-10 Research News It’s no longer news that exercise tones the brain as well as the body, keeping cognition sharp with age and lowering the risk of Alzheimer’s disease. Exactly how this works remains murky, however. In today’s Science, researchers led by Saul

Yuetiva Robles on Women and Men Differ in Their Genetic Risk for Alzheimer’s Progression

COMMENT The findings of this paper are interesting and add some further food for thought in the search for an explanation as to why we observe differences between men and women in the onset and progression of AD. It is interesting to note that there was no differ

PAPER Janulewicz PA, Seth RK, Carlson JM, Ajama J, Quinn E, Heeren T, Klimas N, Lasley SM, Horner RD, Sullivan K, Chatterjee S

The Gut-Microbiome in Gulf War Veterans: A Preliminary Report.

Int J Environ Res Public Health. 2019 Oct 4;16(19) PubMed: 31590322

PAPER Alhasson F, Das S, Seth R, Dattaroy D, Chandrashekaran V, Ryan CN, Chan LS, Testerman T, Burch J, Hofseth LJ, Horner R, Nagarkatti M, Nagarkatti P, Lasley SM, Chatterjee S

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation.

PLoS One. 2017;12(3):e0172914. Epub 2017 Mar 22 PubMed: 28328972

PAPER Gontier G, Iyer M, Shea JM, Bieri G, Wheatley EG, Ramalho-Santos M, Villeda SA

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain.

Cell Rep. 2018 Feb 20;22(8):1974-1981. PubMed: 29466726

PAPER Khrimian L, Obri A, Ramos-Brossier M, Rousseaud A, Moriceau S, Nicot AS, Mera P, Kosmidis S, Karnavas T, Saudou F, Gao XB, Oury F, Kandel E, Karsenty G

Gpr158 mediates osteocalcin's regulation of cognition.

J Exp Med. 2017 Oct 2;214(10):2859-2873. Epub 2017 Aug 29 PubMed: 28851741

PAPER Horowitz AM, Fan X, Bieri G, Smith LK, Sanchez-Diaz CI, Schroer AB, Gontier G, Casaletto KB, Kramer JH, Williams KE, Villeda SA

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.

Science. 2020 Jul 10;369(6500):167-173. PubMed: 32646997