PAPER Neumann M, Frick P, Paron F, Kosten J, Buratti E, Mackenzie IR

Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD-TDP subtypes.

Acta Neuropathol. 2020 Nov;140(5):645-658. Epub 2020 Aug 10 PubMed: 32778941

PAPER Cullen NC, Zetterberg H, Insel PS, Olsson B, Andreasson U, Alzheimer’s Disease Neuroimaging Initiative, Blennow K, Hansson O, Mattsson-Carlgren N

Comparing progression biomarkers in clinical trials of early Alzheimer's disease.

Ann Clin Transl Neurol. 2020 Sep;7(9):1661-1673. Epub 2020 Aug 11 PubMed: 32779869

At AAIC, Hints of Target Engagement for Some Drug Candidates

CONFERENCE COVERAGE 2020-08-12 Conference Coverage This year’s virtual Alzheimer’s Association International Conference featured no new efficacy data from large clinical trials, but there were some snippets of news from early phase studies. CT1812 by Cognition Therapeutics (CogRx) seem

Umibecestat-Driven Cognitive Decline Is Reversible

CONFERENCE COVERAGE 2020-08-12 Conference Coverage At this year’s virtual Alzheimer’s Association International Conference, researchers from Novartis and the Banner Alzheimer’s Institute presented highly anticipated follow-up data from the massive Generation 1 and 2 Phase 3 trials. The

Sam Gandy on Can an Antibody Allele Boost Your Alzheimer’s Risk By Giving Herpes an Edge?

COMMENT The coronavirus pandemic has placed in stark relief our primitive understanding of virology and the complications caused by viral infection because of immunological, immunogenetic, inflammatory, coagulopathic, and vasculopathic events. This an especially

PAPER Rikos D, Marogianni C, Provatas A, Bourinaris T, Arnaoutoglou M, Stathis P, Patrinos GP, Dardiotis E, Hadjigeorgiou GM, Xiromerisiou G

Screening for the C9ORF72 expansion in Greek Huntington Disease phenocopies and controls and meta-analysis of current data.

Tremor Other Hyperkinet Mov (N Y). 2020 Jun 12;10:5. PubMed: 32775019

PAPER Siokas V, Aloizou AM, Tsouris Z, Liampas I, Aslanidou P, Dastamani M, Brotis AG, Bogdanos DP, Hadjigeorgiou GM, Dardiotis E

Genetic Risk Factors for Essential Tremor: A Review.

Tremor Other Hyperkinet Mov (N Y). 2020 Jun 11;10:4. PubMed: 32775018

PAPER Kwa L, Larson D, Yeh C, Bega D

Influence of Age of Onset on Huntington's Disease Phenotype.

Tremor Other Hyperkinet Mov (N Y). 2020 Jul 9;10:21. PubMed: 32775035

PAPER Jaini A, Yomtoob J, Yeh C, Bega D

Understanding HD Psychosis: An Analysis from the ENROLL-HD Database.

Tremor Other Hyperkinet Mov (N Y). 2020 Jul 7;10:16. PubMed: 32775030

PAPER Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JA

Cerebrospinal and blood levels of amino acids as potential biomarkers for Parkinson's disease: review and meta-analysis.

Eur J Neurol. 2020 Nov;27(11):2336-2347. Epub 2020 Sep 11 PubMed: 32777152

PAPER Santos-García D, Oreiro M, Pérez P, Fanjul G, Paz González JM, Feal Painceiras MJ, Cores Bartolomé C, Valdés Aymerich L, García Sancho C, Castellanos Rodrigo MD

Impact of Coronavirus Disease 2019 Pandemic on Parkinson's Disease: A Cross-Sectional Survey of 568 Spanish Patients.

Mov Disord. 2020 Oct;35(10):1712-1716. Epub 2020 Sep 22 PubMed: 32776601

PAPER Bugalho P, Ladeira F, Barbosa R, Marto JP, Borbinha C, Salavisa M, da Conceição L, Saraiva M, Fernandes M, Meira B

Do dreams tell the future? Dream content as a predictor of cognitive deterioration in Parkinson's disease.

J Sleep Res. 2020 Aug 9;:e13163. PubMed: 32776436

PAPER Kukkle PL, Geetha TS, Mahadevan A, Ramprasad VL

A Case of Autosomal Dominant Ataxia with Vocal Cord Palsy Attributed to a Mutation in the PRNP Gene.

Mov Disord Clin Pract. 2020 Aug;7(6):688-692. Epub 2020 Jul 27 PubMed: 32775516

PAPER Freeman DM, Wang Z

Epigenetic Vulnerability of Insulator CTCF Motifs at Parkinson's Disease-Associated Genes in Response to Neurotoxicant Rotenone.

Front Genet. 2020;11:627. Epub 2020 Jul 7 PubMed: 32774342

PAPER Daida K, Nishioka K, Li Y, Yoshino H, Shimada T, Dougu N, Nakatsuji Y, Ohara S, Hashimoto T, Okiyama R, Yokochi F, Suzuki C, Tomiyama M, Kimura K, Ueda N, Tanaka F, Yamada H, Fujioka S, Tsuboi Y, Uozumi T, Takei T, Matsuzaki S, Shibasaki M, Kashihara K, Kurisaki R, Yamashita T, Fujita N, Hirata Y, Ii Y, Wada C, Eura N, Sugie K, Higuchi Y, Kojima F, Imai H, Noda K, Shimo Y, Funayama M, Hattori N

PLA2G6 variants associated with the number of affected alleles in Parkinson's disease in Japan.

Neurobiol Aging. 2021 Jan;97:147.e1-147.e9. Epub 2020 Jul 13 PubMed: 32771225