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William Eimer


Massachusetts General Hospital, Harvard
Charlestown, United States

Even Without Amyloid, ApoE4 Weakens Blood-Brain Barrier, Cognition

RESEARCH NEWS 2020-05-09 Research News ApoE4 weakens the blood-brain barrier in the hippocampus, and in this way takes its toll on cognition, according to a study published April 29 in Nature. Researchers led by Berislav Zlokovic of the University of Southern California in Los ...

PAPER Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TL, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.

Nature. 2020 May;581(7806):71-76. Epub 2020 Apr 29 PubMed: 32376954

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