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Joshua Shulman on Tau, Speckle Wrecker, Disrupts the Nuclear Home

COMMENT This interesting work adds to a growing number of reports that tau can co-aggregate with RNA and RNA-binding proteins. Lester and colleagues further show that this leads to disruptions in nuclear compartments, such as speckles, that have critical roles in

Bess Frost on Tau, Speckle Wrecker, Disrupts the Nuclear Home

COMMENT This lovely study from the Parker lab further implicates tau as a splicing disruptor and identifies RNAs that are sequestered within tau aggregates (Raj et al., 2018; Apicco et al., 2019; Hsieh et al., 2019).  While the mechanistic aspect of the paper foc

W.H. Robichaux


Tulane University Health Sciences Center
Thibodaux, United States

PAPER van der Welle RE, Jobling R, Burns C, Sanza P, van der Beek JA, Fasano A, Chen L, Zwartkruis FJ, Zwakenberg S, Griffin EF, Ten Brink C, Veenendaal T, Liv N, van Ravenswaaij-Arts CM, Lemmink HH, Pfundt R, Blaser S, Sepulveda C, Lozano AM, Yoon G, Santiago-Sim T, Asensio CS, Caldwell GA, Caldwell KA, Chitayat D, Klumperman J

Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation.

EMBO Mol Med. 2021 May 7;13(5):e13258. Epub 2021 Apr 14 PubMed: 33851776

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