PAPER Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L
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Lance Johnson on APOE Tied to Increased Susceptibility to SARS-CoV-2
COMMENT This fascinating study by Wang et al. further expands the already numerous roles of Apolipoprotein E (APOE) in health and disease to now include the world’s major public health challenge, COVID-19. The authors employ a variety of human iPSC lines and brai
PAPER Niu W, Qi Y, Qian Y, Gao P, Zhu D
The relationship between apolipoprotein E epsilon2/epsilon3/epsilon4 polymorphisms and hypertension: a meta-analysis of six studies comprising 1812 cases and 1762 controls.
Hypertens Res. 2009 Dec;32(12):1060-6. Epub 2009 Oct 9 PubMed: 19816504PAPER Gordon EM, Yao X, Xu H, Karkowsky W, Kaler M, Kalchiem-Dekel O, Barochia AV, Gao M, Keeran KJ, Jeffries KR, Levine SJ
Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects.
J Allergy Clin Immunol. 2019 Aug;144(2):426-441.e3. Epub 2019 Mar 11 PubMed: 30872118PAPER Dias SS, Soares VC, Ferreira AC, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, Teixeira L, Nunes da Silva MA, Barreto E, Mattos M, de Freitas CS, Azevedo-Quintanilha IG, Manso PP, Miranda MD, Siqueira MM, Hottz ED, Pão CR, Bou-Habib DC, Barreto-Vieira DF, Bozza FA, Souza TM, Bozza PT
Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators.
PLoS Pathog. 2020 Dec;16(12):e1009127. Epub 2020 Dec 16 PubMed: 33326472Jessica Young on APOE Tied to Increased Susceptibility to SARS-CoV-2
COMMENT This is an interesting and timely work using hiPSC-derived neural models to understand the potential implications of SARS-CoV-2 infection in the brain. While neurological symptoms have been attributed to infection, the mechanisms behind these symptoms are
Rik van der Kant, Diederik van de Beek on APOE Tied to Increased Susceptibility to SARS-CoV-2
COMMENT ApoE isoform-dependent SARS-CoV-2 neurotropism and cellular response The paper by Wang, Zhang, and colleagues suggests that ApoE4/4 neurons and astrocytes are more readily infected by SARS-CoV2 than ApoE3/3 neurons. This finding is interesting but the cli
PAPER Koros C, Simitsi AM, Papagiannakis N, Bougea A, Prentakis A, Papadimitriou D, Pachi I, Antonelou R, Angelopoulou E, Beratis I, Bozi M, Papageorgiou SG, Trapali XG, Stamelou M, Stefanis L
Serum uric acid level as a putative biomarker in Parkinson's disease patients carrying GBA1 mutations: 2-Year data from the PPMI study.
Parkinsonism Relat Disord. 2021 Mar;84:1-4. Epub 2021 Jan 20 PubMed: 33508700PAPER Ho SL, Ho PW, Siu DC
Parkinson disease and leucine-rich repeat kinase 2 gene mutation: abridged secondary publication.
Hong Kong Med J. 2020 Dec;26 Suppl 8(6):22-26. PubMed: 33504674PAPER Lai TH, Toussaint M, Teodoro R, Dukić-Stefanović S, Kranz M, Deuther-Conrad W, Moldovan RP, Brust P
Synthesis and Biological Evaluation of a Novel 18F-Labeled Radiotracer for PET Imaging of the Adenosine A2A Receptor.
Int J Mol Sci. 2021 Jan 25;22(3) PubMed: 33504051PAPER Sobański M, Zacharzewska-Gondek A, Waliszewska-Prosół M, Sąsiadek MJ, Zimny A, Bladowska J
A Review of Neuroimaging in Rare Neurodegenerative Diseases.
Dement Geriatr Cogn Disord. 2020;49(6):544-556. Epub 2021 Jan 28 PubMed: 33508841PAPER Lefèvre-Arbogast S, Hejblum BP, Helmer C, Klose C, Manach C, Low DY, Urpi-Sarda M, Andres-Lacueva C, González-Domínguez R, Aigner L, Altendorfer B, Lucassen PJ, Ruigrok SR, De Lucia C, Du Preez A, Proust-Lima C, Thuret S, Korosi A, Samieri C
Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study.
EBioMedicine. 2021 Feb;64:103216. Epub 2021 Jan 25 PubMed: 33508744PAPER Baek SY, Li FY, Kim JH, Ahn C, Kim HJ, Kim MR
Protein Hydrolysate of Silkworm Pupa Prevents Memory Impairment Induced by Oxidative Stress in Scopolamine-Induced Mice via Modulating the Cholinergic Nervous System and Antioxidant Defense System.
Prev Nutr Food Sci. 2020 Dec 31;25(4):389-399. PubMed: 33505933PAPER Etxeberria-Rekalde E, Alzola-Aldamizetxebarria S, Flunkert S, Hable I, Daurer M, Neddens J, Hutter-Paier B
Quantification of Huntington's Disease Related Markers in the R6/2 Mouse Model.
Front Mol Neurosci. 2020;13:617229. Epub 2021 Jan 11 PubMed: 33505246PAPER Paradise M, Crawford JD, Lam BC, Wen W, Kochan NA, Makkar S, Dawes L, Trollor J, Draper B, Brodaty H, Sachdev PS
Association of Dilated Perivascular Spaces With Cognitive Decline and Incident Dementia.
Neurology. 2021 Mar 16;96(11):e1501-e1511. Epub 2021 Jan 27 PubMed: 33504642Current Filters
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