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Huntingtin Repeats Cause—FTD, Caveolin Variants—ALS?

RESEARCH NEWS 2020-12-24 Research News Geneticists have added two more genes to the list of genetic risk factors for amyotrophic lateral sclerosis and frontotemporal dementia. In Cell Reports on December 1, Johnathan Cooper-Knock, Pamela Shaw, and colleagues at the University of

PAPER Berghoff SA, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Stadelmann-Nessler C, Edgar JM, Nave KA, Saher G

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.

Nat Neurosci. 2021 Jan;24(1):47-60. Epub 2020 Dec 21 PubMed: 33349711

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