PAPER Ittisoponpisan S, David A

Structural Biology Helps Interpret Variants of Uncertain Significance in Genes Causing Endocrine and Metabolic Disorders.

J Endocr Soc. 2018 Aug 1;2(8):842-854. Epub 2018 Jun 13 PubMed: 30019023

PAPER Orth M, Weng W, Funke H, Steinmetz A, Assmann G, Nauck M, Dierkes J, Ambrosch A, Weisgraber KH, Mahley RW, Wieland H, Luley C

Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28--> Pro), on lipoproteins and the prevalence of coronary artery disease in whites.

Arterioscler Thromb Vasc Biol. 1999 May;19(5):1306-15. PubMed: 10323784

PAPER Wintjens R, Bozon D, Belabbas K, MBou F, Girardet JP, Tounian P, Jolly M, Boccara F, Cohen A, Karsenty A, Dubern B, Carel JC, Azar-Kolakez A, Feillet F, Labarthe F, Gorsky AM, Horovitz A, Tamarindi C, Kieffer P, Lienhardt A, Lascols O, Di Filippo M, Dufernez F

Global molecular analysis and APOE mutations in a cohort of autosomal dominant hypercholesterolemia patients in France.

J Lipid Res. 2016 Mar;57(3):482-91. Epub 2016 Jan 22 PubMed: 26802169

Virginie Lecomte Maloney

University of Technology Sydney
Syndey, Australia

PAPER Saunders AJ, Kim TW, Tanzi RE

BACE maps to chromosome 11 and a BACE homolog, BACE2, reside in the obligate Down’s syndrome region of chromosome 21

Science 1999 Nov 12;(286):1255a.

Yun Zhang, Weihong Song on Can BACE2 Protect Against Amyloidosis?

COMMENT Human BACE2 is an aspartyl protease, encoded by the BACE2 gene on chromosome 21 (Acquati et al., 2000; Bennett et al., 2000; Lin et al., 2000). BACE2 is homologous to BACE1 (the β-secretase). These two proteins are 45 percent identical in amino acid seque

Stefan Lichtenthaler on Can BACE2 Protect Against Amyloidosis?

COMMENT This paper is a technical tour de force and elegantly demonstrates the relevance of BACE2 as an anti-amyloidogenic protease, at least in trisomy 21 cerebral organoids. It also opens the exciting possibility that SNPs in BACE2 may control the age of onset

PAPER Solans A, Estivill X, de La Luna S

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase.

Cytogenet Cell Genet. 2000;89(3-4):177-84. PubMed: 10965118

Can BACE2 Protect Against Amyloidosis?

RESEARCH NEWS 2020-02-18 Research News It may seem counterintuitive, but could BACE2 protect against amyloidosis, rather than contribute to it? This is the central question in a manuscript posted to bioRxiv. Non-amyloidogenic processing of APP, and Aβ peptides, by BACE2 may count

Yun Zhang

University of British Columbia

Maggie Appleton

Camila Almeida

Goleta, United States

Vicky Cutler

United States

PAPER Shrivastava AN, Bousset L, Renner M, Redeker V, Savistchenko J, Triller A, Melki R

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs.

Biophys J. 2020 Mar 24;118(6):1301-1320. Epub 2020 Jan 28 PubMed: 32059758

PAPER McKinnon C, De Snoo ML, Gondard E, Neudorfer C, Chau H, Ngana SG, O'Hara DM, Brotchie JM, Koprich JB, Lozano AM, Kalia LV, Kalia SK

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein.

Acta Neuropathol Commun. 2020 Feb 14;8(1):17. PubMed: 32059750