PAPER Bakker C, van der Aart J, Hart EP, Klaassen ES, Bergmann KR, van Esdonk MJ, Kay DG, Groeneveld GJ

Safety, pharmacokinetics, and pharmacodynamics of Gln-1062, a prodrug of galantamine.

Alzheimers Dement (N Y). 2020;6(1):e12093. Epub 2020 Oct 13 PubMed: 33083515

PAPER Yu X, Nagai J, Marti-Solano M, Soto JS, Coppola G, Babu MM, Khakh BS

Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable.

Neuron. 2020 Dec 23;108(6):1146-1162.e10. Epub 2020 Oct 20 PubMed: 33086039

"Science Webinar"- Deciphering Microglia: Exploring Cellular Pathways in Neurodegenerative Diseases

CONFERENCE 2020-10-28 00:00:00-2020-10-28 00:00:00 Online Meeting 28 October 2020 Speakers: Michael Heneka, PhD, German Center for Neurodegenerative Diseases in Bonn, and Christian Haass, PhD, German Center for Neurodegenerative Diseases in Munich Moderator: Sean Sanders, PhD, Science Magazine / AAAS, Was

Largest Alzheimer GWAS in African Americans Finds New Variants

RESEARCH NEWS 2020-10-22 Research News African Americans have about double the risk of dementia as their non-Hispanic white peers. How much of this is genetics, how much is environment? With the biggest genome-wide association study on African Americans to date, researchers led b

PAPER Laster M, Shen JI, Norris KC

Kidney Disease Among African Americans: A Population Perspective.

Am J Kidney Dis. 2018 Nov;72(5 Suppl 1):S3-S7. PubMed: 30343720

PAPER Zhang H, Zhou H, Lencz T, Farrer LA, Kranzler HR, Gelernter J

Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test.

Am J Med Genet B Neuropsychiatr Genet. 2018 Jul;177(5):511-519. PubMed: 30134085

PSEN2 P436L

MUTATIONS PSEN2 227083240 GRCh37/hg19 C T Exon 13 Point, Missense Coding Unknown. Unknown, but MRI of one carrier showed bilateral atrophy of the temporal lobe and hippocampus. P436L Dementia: Not ClassifiedAlzheimer's Disease This variant was identified in a

Alyssa Rodriguez

UCI
Irvine, United States

Daniel Otzen on Blunt Instruments: α-Synuclein Antibodies Poorly Distinguish Forms

COMMENT This is a tour de force assessment of different antibodies previously reported to be specific for certain types of α-synuclein aggregate. They are not! I commend the authors for this thorough, systematic, honest, and self-critical approach to preparing sa

Do Endothelial Cells Spur Capillaries to Grow in Alzheimer’s Brain?

RESEARCH NEWS 2020-10-22 Research News Endothelial cells tend to get short shrift in studies of Alzheimer’s, but new results now implicate these cells in the toxic brain environment of people with this disease. In the September 28 Proceedings of the National Academy of Sciences,

Daniel Otzen

Aarhus University
Aarhus C, Denmark

PAPER Agostinho P, Madeira D, Dias L, Simões AP, Cunha RA, Canas PM

Purinergic signaling orchestrating neuron-glia communication.

Pharmacol Res. 2020 Dec;162:105253. Epub 2020 Oct 17 PubMed: 33080321

PAPER Tremblay S, Acker L, Afraz A, Albaugh DL, Amita H, Andrei AR, Angelucci A, Aschner A, Balan PF, Basso MA, Benvenuti G, Bohlen MO, Caiola MJ, Calcedo R, Cavanaugh J, Chen Y, Chen S, Chernov MM, Clark AM, Dai J, Debes SR, Deisseroth K, Desimone R, Dragoi V, Egger SW, Eldridge MA, El-Nahal HG, Fabbrini F, Federer F, Fetsch CR, Fortuna MG, Friedman RM, Fujii N, Gail A, Galvan A, Ghosh S, Gieselmann MA, Gulli RA, Hikosaka O, Hosseini EA, Hu X, Hüer J, Inoue KI, Janz R, Jazayeri M, Jiang R, Ju N, Kar K, Klein C, Kohn A, Komatsu M, Maeda K, Martinez-Trujillo JC, Matsumoto M, Maunsell JH, Mendoza-Halliday D, Monosov IE, Muers RS, Nurminen L, Ortiz-Rios M, O'Shea DJ, Palfi S, Petkov CI, Pojoga S, Rajalingham R, Ramakrishnan C, Remington ED, Revsine C, Roe AW, Sabes PN, Saunders RC, Scherberger H, Schmid MC, Schultz W, Seidemann E, Senova YS, Shadlen MN, Sheinberg DL, Siu C, Smith Y, Solomon SS, Sommer MA, Spudich JL, Stauffer WR, Takada M, Tang S, Thiele A, Treue S, Vanduffel W, Vogels R, Whitmire MP, Wichmann T, Wurtz RH, Xu H, Yazdan-Shahmorad A, Shenoy KV, DiCarlo JJ, Platt ML

An Open Resource for Non-human Primate Optogenetics.

Neuron. 2020 Dec 23;108(6):1075-1090.e6. Epub 2020 Oct 19 PubMed: 33080229

PAPER Gao X, Huang Z, Feng C, Guan C, Li R, Xie H, Chen J, Li M, Que R, Deng B, Cao P, Li M, Lu J, Huang Y, Li M, Yang W, Yang X, Wen C, Liang X, Yang Q, Chao YX, Chan LL, Yenari MA, Jin K, Chaudhuri KR, Zhang J, Tan EK, Wang Q

Multimodal analysis of gene expression from postmortem brains and blood identifies synaptic vesicle trafficking genes to be associated with Parkinson's disease.

Brief Bioinform. 2020 Oct 20; PubMed: 33079984

PAPER Jiang Y, Guo Z, McClure MA, He L, Mu Q

Effect of rTMS on Parkinson's cognitive function: a systematic review and meta-analysis.

BMC Neurol. 2020 Oct 19;20(1):377. PubMed: 33076870