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Human and Mouse Microglia React Differently to Amyloid

RESEARCH NEWS 2020-01-17 Research News Transgenic mice fail to capture many aspects of Alzheimer’s disease, and a new transcriptional study lays bare one reason. Brain cells in the two species, it turns out, respond quite differently to amyloidosis. In the January 13 Nature Medic

Bace1 conditional knockout (Tesco)

RESEARCH MODELS Summary This is the second of two similar models designed to mimic BACE1 inhibition, in which researchers can control the timing of BACE1 deficiency. These conditional knockouts avoid the developmental effects of BACE1 deficiency that are seen in germline

PAPER Narita A, Shirai K, Itamura S, Matsuda A, Ishihara A, Matsushita K, Fukuda C, Kubota N, Takayama R, Shigematsu H, Hayashi A, Kumada T, Yuge K, Watanabe Y, Kosugi S, Nishida H, Kimura Y, Endo Y, Higaki K, Nanba E, Nishimura Y, Tamasaki A, Togawa M, Saito Y, Maegaki Y, Ohno K, Suzuki Y

Ambroxol chaperone therapy for neuronopathic Gaucher disease: A pilot study.

Ann Clin Transl Neurol. 2016 Mar;3(3):200-15. Epub 2016 Feb 2 PubMed: 27042680

Wiep Scheper on Does Tau Kill Neurons by Way of Necroptosis?

COMMENT This extensive and well-performed study by Koper et al. shows an interesting novel feature of GVBs, as their core is immunopositive for necrosomes. As the authors and commentators indicate, caution is warranted with mechanistic interpretation based on obs

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