PAPER Wislet-Gendebien S, D'Souza C, Kawarai T, St George-Hyslop P, Westaway D, Fraser P, Tandon A

Withdrawal: Cytosolic proteins regulate α-synuclein dissociation from presynaptic membranes.

J Biol Chem. 2020 Sep 25;295(39):13694. PubMed: 32978332

Luke Miles on Of Four Aβ Antibodies, Only Aducanumab Stems Tide of Toxic Oligomers

COMMENT Linse et al. present a kinetic study of the influence of four amyloid-directed antibodies, developed to treat Alzheimer’s disease, on aspects of the complex process of amyloid-β aggregation. This is an advancement on our own efforts and those of others to ...

PAPER Twaddle AC

Swedish physicians' perspectives on work and the medical care system--V. Comparisons across specialties.

Soc Sci Med. 1989;29(10):1207-16. PubMed: 2588048

Of Four Aβ Antibodies, Only Aducanumab Stems Tide of Toxic Oligomers

RESEARCH NEWS 2020-09-28 Research News A slew of anti-Aβ antibodies have been developed for clinical trials, in hopes that they will spur the immune system to remove amyloid-β from the brain. But might they also shift the dynamic of Aβ aggregation? According to a paper published ...

PAPER Linse S, Scheidt T, Bernfur K, Vendruscolo M, Dobson CM, Cohen SI, Sileikis E, Lundqvist M, Qian F, O'Malley T, Bussiere T, Weinreb PH, Xu CK, Meisl G, Devenish SR, Knowles TP, Hansson O

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies.

Nat Struct Mol Biol. 2020 Dec;27(12):1125-1133. Epub 2020 Sep 28 PubMed: 32989305

PAPER Arosio P, Müller T, Rajah L, Yates EV, Aprile FA, Zhang Y, Cohen SI, White DA, Herling TW, De Genst EJ, Linse S, Vendruscolo M, Dobson CM, Knowles TP

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions.

ACS Nano. 2016 Jan 26;10(1):333-41. Epub 2015 Dec 23 PubMed: 26678709

PAPER Cohen SI, Vendruscolo M, Dobson CM, Knowles TP

From macroscopic measurements to microscopic mechanisms of protein aggregation.

J Mol Biol. 2012 Aug 10;421(2-3):160-71. Epub 2012 Mar 8 PubMed: 22406275

Lee-Way Jin

University of California Davis
Sacramento, United States

Mounica Neravetla

ApoE Symposium- MGH-MAPP

CONFERENCE 2021-01-22 00:00:00-2021-01-22 00:00:00 Online Meeting 22 January 2021 View Conference Website 0 ...

Annie Winkler

United Kingdom

Abla Creasey

California Institute for Regenerative Medicine
Oakland, United States

Manfredi Carta

University of Zurich
Zurich, Switzerland

Stephen Strittmatter on Nixing TMEM106b Fans the Flames of Progranulin Deficiency

COMMENT We are delighted that the three TMEM106B/PGRN double knockout studies from Zhou et al., Feng et al., and Werner et al. have further clarified the genetic interactions between TMEM106B and GRN. Full deletion of both genes clearly causes a synthetic lethal ...

Ekta Patel