End of the BACE Inhibitors? Elenbecestat Trials Halted Amid Safety Concerns

RESEARCH NEWS 2019-09-13 Research News Marking the fall of the only remaining BACE inhibitor currently being tested for AD, Biogen and Eisai announced today the discontinuation of two Phase 3 studies of elenbecestat  in people with mild cognitive impairment and mild AD. The compa

L. Gillen

McDaniel College

PAPER Fleming SM, Salcedo J, Hutson CB, Rockenstein E, Masliah E, Levine MS, Chesselet MF

Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein.

Neuroscience. 2006 Nov 3;142(4):1245-53. Epub 2006 Aug 23 PubMed: 16934409

PAPER Fleming SM, Salcedo J, Fernagut PO, Rockenstein E, Masliah E, Levine MS, Chesselet MF

Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.

J Neurosci. 2004 Oct 20;24(42):9434-40. PubMed: 15496679

Results of Ladostigil Trial Published

RESEARCH NEWS 2019-09-13 Research News In a second Phase 2 strikeout, the small-molecule drug ladostigil missed its primary endpoint of curbing progression from mild cognitive impairment to AD, though people on a low-dose regimen did have less brain shrinkage over three years tha

PAPER Weinstock M, Bejar C, Schorer-Apelbaum D, Panarsky R, Luques L, Shoham S

Dose-dependent effects of ladostigil on microglial activation and cognition in aged rats.

J Neuroimmune Pharmacol. 2013 Mar;8(1):345-55. Epub 2013 Jan 17 PubMed: 23325108

Tiny Brain Structure Plays Big Role in Memory

RESEARCH NEWS 2019-09-13 Research News The humble locus coeruleus, a minute speck of tissue nestled deep in the brain stem, has received relatively scant attention in studies of cognitive decline. Now, data published September 9 in Nature Human Behavior add to a recent spate of f

Yanxi Chen

United States

PAPER Dahl MJ, Mather M, Düzel S, Bodammer NC, Lindenberger U, Kühn S, Werkle-Bergner M

Rostral locus coeruleus integrity is associated with better memory performance in older adults.

Nat Hum Behav. 2019 Sep 9; PubMed: 31501542

PAPER Gerstorf D, Bertram L, Lindenberger U, Pawelec G, Demuth I, Steinhagen-Thiessen E, Wagner GG

Editorial.

Gerontology. 2016;62(3):311-5. Epub 2016 Jan 29 PubMed: 26820471

PAPER Manaye KF, McIntire DD, Mann DM, German DC

Locus coeruleus cell loss in the aging human brain: a non-random process.

J Comp Neurol. 1995 Jul 17;358(1):79-87. PubMed: 7560278

Russell Swerdlow on Hello Mitochondriomics: Tagging Method Identifies Different Subtypes

COMMENT This is a very creative methods-development paper that will likely fill a much-needed niche in the mitochondrial research field. Over the past few decades it has increasingly become clear that mitochondria are not equivalent between cell types. For exampl

Mark Cookson on Hello Mitochondriomics: Tagging Method Identifies Different Subtypes

COMMENT The work from Fecher et al. is a very innovative solution to the older problem of estimating if mitochondria in major cell types of the mammalian brain are different. Based on their differing physiology and energetic requirements, it is gratifying, if exp

Maria Ankarcrona on Hello Mitochondriomics: Tagging Method Identifies Different Subtypes

COMMENT In this very nice study, Misgeld’s group has engineered a set of MitoTag mice expressing GFP in the outer mitochondrial membrane (OMM) in a cell-type-specific manner. Importantly, they demonstrate that GFP-OMM-tagged mitochondria can be purified in separa

PAPER Vance JE

Phospholipid synthesis in a membrane fraction associated with mitochondria.

J Biol Chem. 1990 May 5;265(13):7248-56. PubMed: 2332429