PAPER Tomizawa Y, Taniguchi D, Furukawa Y

Genetic Creutzfeldt-Jakob disease mimicking dementia with Lewy bodies: Clinical and radiological findings.

J Neurol Sci. 2020 Feb 15;409:116604. Epub 2019 Nov 28 PubMed: 31805431

PAPER Ding X, Sun F, Chen J, Chen L, Tobin-Miyaji Y, Xue S, Qiang W, Luo SZ

Amyloid-Forming Segment Induces Aggregation of FUS-LC Domain from Phase Separation Modulated by Site-Specific Phosphorylation.

J Mol Biol. 2020 Jan 17;432(2):467-483. Epub 2019 Dec 2 PubMed: 31805282

PAPER Wilson KM, Muralidharan B, Isaacs AM

Relax, Don't RAN Translate It.

Neuron. 2019 Dec 4;104(5):827-829. PubMed: 31805259

PAPER Haller S, Montandon ML, Rodriguez C, Garibotto V, Lilja J, Herrmann FR, Giannakopoulos P

Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging.

Front Neurosci. 2019;13:1228. Epub 2019 Nov 15 PubMed: 31803008

PAPER Harris ML, Titler MG, Struble LM

Acupuncture and Acupressure for Dementia Behavioral and Psychological Symptoms: A Scoping Review.

West J Nurs Res. 2019 Dec 5;:193945919890552. PubMed: 31802723

PAPER Tseng LY, Huang ST, Peng LN, Chen LK, Hsiao FY

Benzodiazepines, z-Hypnotics, and Risk of Dementia: Special Considerations of Half-Lives and Concomitant Use.

Neurotherapeutics. 2020 Jan;17(1):156-164. PubMed: 31802436

Philip Tipton

Mayo Clinic
Jacksonville, United States

SHRSP/FAD

RESEARCH MODELS Summary Pure Alzheimer’s disease—in which brains contain only the pathological hallmarks of AD, amyloid plaques and neurofibrillary tangles—is rare: In one recent study of nearly 900 autopsy samples with AD pathology, approximately 85 percent also exhibit

Keith Vossel on Does a Breached Blood-Brain Barrier Cause Seizures in AD?

COMMENT Milikovsky et al. devised a clever method to quantify discrete episodes of cortical slowing, termed paroxysmal slow-wave events (PSWEs), in AD and determined that these events had unique associations with blood-brain barrier dysfunction and degree of cogn

Does a Breached Blood-Brain Barrier Cause Seizures in AD?

RESEARCH NEWS 2019-12-06 Research News In back-to-back papers in the December 4 Science Translational Medicine, scientists led by Daniela Kaufer, University of California, Berkeley, and Alon Friedman, Ben-Gurion University of the Negev, Beer-Sheva, Israel, report that age-related

Jonathan Schott on Does a Breached Blood-Brain Barrier Cause Seizures in AD?

COMMENT Blood-brain barrier (BBB) dysfunction is increasingly emerging as an early and important mechanism that might underpin some of the cognitive changes seen as part of the aging process and in the development of neurodegenerative diseases, including Alzheime

Costantino Iadecola on Does a Breached Blood-Brain Barrier Cause Seizures in AD?

COMMENT What is new? The link between astrocytes and BBB dysfunction in aging is new and expands our understanding of the cellular bases of the pathogenic impact of the BBB on brain function and of the signaling mechanisms involved (TGFβ-SMAD etc.). I find it of

PAPER Hasegawa M, Jakes R, Crowther RA, Lee VM, Ihara Y, Goedert M

Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.

FEBS Lett. 1996 Apr 8;384(1):25-30. PubMed: 8797796

Berislav Zlokovic on Does a Breached Blood-Brain Barrier Cause Seizures in AD?

COMMENT These papers by Senatorov et al. and Milikovsky et al. demonstrate that BBB dysfunction initiates neuronal dysfunction, supporting the growing body of evidence that BBB breakdown contributes to synaptic dysfunction, neurodegeneration, and cognitive impair

PAPER Rabender C, Mezzaroma E, Mauro AG, Mullangi R, Abbate A, Anscher M, Hart B, Mikkelsen R

IPW-5371 Proves Effective as a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects.

Radiat Res. 2016 Nov;186(5):478-488. PubMed: 27841740