PAPER Godoy PA, Ramírez-Molina O, Fuentealba J31787900
PAPER Caselli RJ, Langlais BT, Dueck AC, Chen Y, Su Y, Locke DE, Woodruff BK, Reiman EM31787561
PAPER Meilandt WJ, Maloney JA, Imperio J, Lalehzadeh G, Earr T, Crowell S, Bainbridge TW, Lu Y, Ernst JA, Fuji RN, Atwal JK
Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ.Alzheimers Res Ther. 2019 Dec 1;11(1):97. PubMed: 31787113
PAPER Pérez-Grijalba V, Arbizu J, Romero J, Prieto E, Pesini P, Sarasa L, Guillen F, Monleón I, San-José I, Martínez-Lage P, Munuera J, Hernández I, Buendía M, Sotolongo-Grau O, Alegret M, Ruiz A, Tárraga L, Boada M, Sarasa M, AB255 Study Group
Plasma Aβ42/40 ratio alone or combined with FDG-PET can accurately predict amyloid-PET positivity: a cross-sectional analysis from the AB255 Study.Alzheimers Res Ther. 2019 Dec 1;11(1):96. PubMed: 31787105
PAPER Jia X, Wang Z, Yang T, Li Y, Gao S, Wu G, Jiang T, Liang P31788334
KRIBBKorea, Republic of
THERAPEUTICS Alzheon Inc. NRM-8499, homotaurine, 3-APS Small Molecule Amyloid-Related Alzheon published results of a Phase 1 study of safety, tolerability, and pharmacokinetics of single and multiple doses of ALZ-801 in 127 healthy, old volunteers (Hey et al., 2018). ...
COMMENT A great deal of preclinical work in gene therapy for diverse neurological diseases has been conducted over the past 20 years. The technologies for both antisense and viral-vector-based delivery are finally becoming mature, and without a doubt will be ...
COMMENT Grubman et al. present a data set of single nuclei sequencing of entorhinal cortex tissue derived from the brains of six Alzheimer’s disease (AD) patients and six age-matched control patients. This report, combined with the data set recently published by ...
Dementia ServicesSheffield, United Kingdom
PAPER Liu S, Pan J, Tang K, Lei Q, He L, Meng Y, Cai X, Li Z
Sleep spindles, K-complexes, limb movements and sleep stage proportions may be biomarkers for amnestic mild cognitive impairment and Alzheimer's disease.Sleep Breath. 2019 Nov 30; PubMed: 31786748
PAPER Winneroski LL, Erickson JA, Green SJ, Lopez JE, Stout SL, Porter WJ, Timm DE, Audia JE, Barberis M, Beck JP, Boggs LN, Borders AR, Boyer RD, Brier RA, Hembre EJ, Hendle J, Garcia-Losada P, Minguez JM, Mathes BM, May PC, Monk SA, Rankovic Z, Shi Y, Watson BM, Yang Z, Mergott DJ
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.Bioorg Med Chem. 2020 Jan 1;28(1):115194. Epub 2019 Nov 15 PubMed: 31786008
PAPER E Elahi GM, Kalra S, Zinman L, Genge A, Korngut L, Yang YH31786374