PAPER Ye Y, Klenerman D, Finley D

N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme.

J Mol Biol. 2020 Jan 17;432(2):585-596. Epub 2019 Sep 10 PubMed: 31518613

PAPER Lee PC, Artaud F, Cormier-Dequaire F, Rascol O, Durif F, Derkinderen P, Marques AR, Bourdain F, Brandel JP, Pico F, Lacomblez L, Bonnet C, Brefel-Courbon C, Ory-Magne F, Grabli D, Klebe S, Mangone G, You H, Mesnage V, Brice A, Vidailhet M, Corvol JC, Elbaz A, DIGPD Study Group

Examining the Reserve Hypothesis in Parkinson's Disease: A Longitudinal Study.

Mov Disord. 2019 Nov;34(11):1663-1671. Epub 2019 Sep 13 PubMed: 31518456

PAPER Singleton A, Hardy J

Progress in the genetic analysis of Parkinson's disease.

Hum Mol Genet. 2019 Nov 21;28(R2):R215-R218. PubMed: 31518392

PAPER Walton CC, Lampit A, Boulamatsis C, Hallock H, Barr P, Ginige JA, Brodaty H, Chau T, Heffernan M, Sachdev PS, Fiatarone Singh MA, Valenzuela M

Design and Development of the Brain Training System for the Digital "Maintain Your Brain" Dementia Prevention Trial.

JMIR Aging. 2019 Feb 27;2(1):e13135. PubMed: 31518277

PAPER Guisado-Fernández E, Giunti G, Mackey LM, Blake C, Caulfield BM

Factors Influencing the Adoption of Smart Health Technologies for People With Dementia and Their Informal Caregivers: Scoping Review and Design Framework.

JMIR Aging. 2019 Apr 30;2(1):e12192. PubMed: 31518262

PAPER Liu Y, Aguzzi A

NG2 glia are required for maintaining microglia homeostatic state.

Glia. 2020 Feb;68(2):345-355. Epub 2019 Sep 13 PubMed: 31518022

PAPER Harris AR, McGivern P, Ooi L

Modeling Emergent Properties in the Brain Using Tissue Models to Investigate Neurodegenerative Disease.

Neuroscientist. 2019 Sep 13;:1073858419870446. PubMed: 31517587

PAPER Domingos S, Duarte T, Saraiva L, Guedes RC, Moreira R

Targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of Parkinson's disease.

Future Med Chem. 2019 Aug;11(15):1953-1977. PubMed: 31517532

PAPER Gonçalves AC, Marques A, Samuel D, Demain S

Outcomes of physical activity for people living with dementia: qualitative study to inform a Core Outcome Set.

Physiotherapy. 2019 Jun 2; PubMed: 31515072

PAPER Tian J, Shi J, Wei M, Ni J, Fang Z, Gao J, Wang H, Yao H, Zhang J, Li J, Min M, Su L, Sun X, Wang B, Wang B, Yang F, Zou Y, Hu Y, Lin Y, Xu G, Li K, Li L, Zhen H, Xu J, Chen K, Wang Y, CHARM study group

Chinese herbal medicine Qinggongshoutao for the treatment of amnestic mild cognitive impairment: A 52-week randomized controlled trial.

Alzheimers Dement (N Y). 2019;5:441-449. Epub 2019 Sep 4 PubMed: 31517031

Abed Mansour

Salk Institute for Biological Studies
San Diego, United States

Jason Ulrich on Among AD Mutations, Only ApoE4 Seems to Hobble Microglia

COMMENT Konttinen and coworkers add to the rapidly growing body of work examining the effect of AD risk factors using induced human microglia derived from iPSCs. The observed reductions in phagocytosis and increased inflammatory cytokine production in APOE4 micro

Julia TCW on Among AD Mutations, Only ApoE4 Seems to Hobble Microglia

COMMENT Konttinen et al. have developed another microglia protocol based on human iPSC-derived primitive (but not definitive) erythromyeloid progenitors induced by hypoxia. The protocol is similar to but slightly simpler than that described by Abud and colleagues

Among AD Mutations, Only ApoE4 Seems to Hobble Microglia

RESEARCH NEWS 2019-09-14 Research News New research adds to the evidence that ApoE regulates microglial health and activity. Researchers led by Tarja Malm at the University of Eastern Finland, Kuopio, examined how several Alzheimer’s risk factors affect microglia generated from h

PAPER Konttinen H, Cabral-da-Silva ME, Ohtonen S, Wojciechowski S, Shakirzyanova A, Caligola S, Giugno R, Ishchenko Y, Hernández D, Fazaludeen MF, Eamen S, Budia MG, Fagerlund I, Scoyni F, Korhonen P, Huber N, Haapasalo A, Hewitt AW, Vickers J, Smith GC, Oksanen M, Graff C, Kanninen KM, Lehtonen S, Propson N, Schwartz MP, Pébay A, Koistinaho J, Ooi L, Malm T

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia.

Stem Cell Reports. 2019 Oct 8;13(4):669-683. Epub 2019 Sep 12 PubMed: 31522977